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publication / 2025
Evidence from spatial transcriptomics for the mosaic hypothesis and pure cell types in the cortex
Cell Reports
Shanahan
Brain Science

Yiliu Wang, Christof Koch, Uygar Sümbül

publication / 2025
Spontaneous pathology in PS19 tauopathy mice progresses via brain networks
Neurobiology of Disease
Brain Science

Denise M. O. Ramirez, Jennifer D. Whitesell, Nikhil Bhagwat, Talitha L. Thomas, Apoorva D. Ajay, Ariana Nawaby, Benoît Delatour, Sylvie Bay, Pierre LaFaye, Julie A. Harris, Julian P. Meeks, Marc I. Diamond

publication / 2025
Data-driven fine-grained region discovery in the mouse brain with transformers
Nature Communications
Brain Science

Alex J. Lee, Alma Dubuc, Michael Kunst, Shenqin Yao, Nicholas Lusk, Lydia Ng, Hongkui Zeng, Bosiljka Tasic, Reza Abbasi-Asl

publication / 2025
What makes the human brain special: from cellular function to clinical translation
Journal of Neurophysiology
Brain Science

Karen M. J. van Loo, Aniella Bak, Rebecca Hodge, Francesco Bedogni, Julian S. B. Ramirez, Samuel N. Emerson, Anke Höllig, Huibert D. Mansvelder, Natalia A. Goriounova, Jan-Marino Ramirez, Henner Koch

publication / 2025
The xIV-LDDMM toolkit of image-varifold based technologies for mapping 3D images and spatial-omics across scales
Communications Biology
Brain Science

Kaitlin M. Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouvé, Michael I. Miller

publication / 2025
Arousal as a universal embedding for spatiotemporal brain dynamics
Nature
Shanahan

Ryan V. Raut, Zachary P. Rosenthal, Xiaodan Wang, Hanyang Miao, Zhanqi Zhang, Jin-Moo Lee, Marcus E. Raichle, Adam Q. Bauer, Steven L. Brunton, Bingni W. Brunton, J. Nathan Kutz

publication / 2025
AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders
Molecular Therapy: The Journal of the American Society of Gene Therapy
Brain Science
Brain Health

Meagan A. Quinlan, Rong Guo, Andrew G. Clark, Emily M. Luber, Robert J. Christian, Refugio A. Martinez, Erin L. Groce, Jiatai Liu, Yemeserach M. Bishaw, Ravi Bhowmik, Elizabeth Liang, Melissa Reding, Kara Ronellenfitch, Vonn Wright, Kathryn M. Gudsnuk, Jennifer M. Leedy, John K. Mich, Bryan B. Gore, Tanya L. Daigle, Manuel E. Lopez, Ed S. Lein, Justin K. Ichida, Boaz P. Levi

publication / 2025
Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals
Cell
Brain Science

Simon Haziza, Radosław Chrapkiewicz, Yanping Zhang, Vasily Kruzhilin, Jane Li, Jizhou Li, Geoffroy Delamare, Rachel Swanson, György Buzsáki, Madhuvanthi Kannan, Ganesh Vasan, Michael Z. Lin, Hongkui Zeng, Tanya L. Daigle, Mark J. Schnitzer

publication / 2025
Impaired capillary-venous drainage contributes to gliosis and demyelination in mouse white matter during aging
Nature Neuroscience
Brain Science

Stefan Stamenkovic, Franca Schmid, Gokce Gurler, Farzaneh Abolmaali, Nicolas A. Weitermann, Kevin T. Takasaki, Stephanie K. Bonney, Maria J. Sosa, Hannah C. Bennett, Yongsoo Kim, Jack Waters, Andy Y. Shih

publication / 2025
Three-photon microscopy: an emerging technique for deep intravital brain imaging
Nature Reviews. Neuroscience
Brain Science

Robert Prevedel, Júlia Ferrer Ortas, Jason N. D. Kerr, Jack Waters, Michael O. Breckwoldt, Benjamin Deneen, Michelle Monje, Stella J. Soyka, Varun Venkataramani

publication / 2025
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
Cell
Brain Science

Richard Drexler, Antonia Drinnenberg, Avishai Gavish, Belgin Yalçin, Kiarash Shamardani, Abigail E. Rogers, Rebecca Mancusi, Vrunda Trivedi, Kathryn R. Taylor, Yoon Seok Kim, Pamelyn J. Woo, Neeraj Soni, Minhui Su, Alexandre Ravel, Eva Tatlock, Alexandra Midler, Samuel H. Wu, Charu Ramakrishnan, Ritchie Chen, Alberto E. Ayala-Sarmiento, David Rincon Fernandez Pacheco, La'Akea Siverts, Tanya L. Daigle, Bosiljka Tasic, Hongkui Zeng, Joshua J. Breunig, Karl Deisseroth, Michelle Monje

publication / 2025
An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Brain Science
Brain Health

Amy F. T. Arnsten, Kelly Del Tredici, Nicolas R. Barthélemy, Mariano Gabitto, Christopher H. van Dyck, Edward Lein, Heiko Braak, Dibyadeep Datta

publication / 2025
The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex
Nature Neuroscience
Brain Science

Agnes L. Bodor, Casey M. Schneider-Mizell, Chi Zhang, Leila Elabbady, Alex Mallen, Andi Bergeson, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Rachel Dalley, Clare Gamlin, Emily Joyce, Daniel Kapner, Sam Kinn, Gayathri Mahalingam, Sharmishtaa Seshamani, Shelby Suckow, Marc Takeno, Russel Torres, Wenjing Yin, J. Alexander Bae, Manuel A. Castro, Sven Dorkenwald, Akhilesh Halageri, Zhen Jia, Chris Jordan, Nico Kemnitz, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina, Eric Mitchell, Shanka Subhra Mondal, Shang Mu, Barak Nehoran, Sergiy Popovych, William Silversmith, Nicholas L. Turner, Szi-Chieh Yu, William Wong, Jingpeng Wu, Brendan Celii, Luke Campagnola, Stephanie C. Seeman, Tim Jarsky, Naixin Ren, Anton Arkhipov, Jacob Reimer, H. Sebastian Seung, R. Clay Reid, Forrest Collman, Nuno Maçarico da Costa

publication / 2025
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Neuron
Brain Science

Melissa E. Murray, Colin Smith, Vilas Menon, C. Dirk Keene, Ed Lein, Michael Hawrylycz, Adriano Aguzzi, Brett Benedetti, Katja Brose, Kelsey Caetano-Anolles, Maria Inmaculada Cobos Sillero, John F. Crary, Philip L. De Jager, Arline Faustin, Margaret E. Flanagan, Ozgun Gokce, Seth G. N. Grant, Lea T. Grinberg, David A. Gutman, Elizabeth M. C. Hillman, Zhi Huang, David J. Irwin, David T. Jones, Alifiya Kapasi, Celeste M. Karch, Walter T. Kukull, Tammaryn Lashley, Edward B. Lee, Thomas Lehner, Laura Parkkinen, Maria Pedersen, Dominique Pritchett, Matthew H. Rutledge, Julie A. Schneider, William W. Seeley, Claire E. Shepherd, Tara L. Spires-Jones, Judith A. Steen, Margaret Sutherland, Sanja Vickovic, Bin Zhang, David J. Stewart, Michael J. Keiser, Jacob W. Vogel, Brittany N. Dugger, Hemali Phatnani

publication / 2025
Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
eLife
Neural Dynamics
Brain Science

Adam Glaser, Jayaram Chandrashekar, Sonya Vasquez, Cameron Arshadi, Rajvi Javeri, Naveen Ouellette, Xiaoyun Jiang, Judith Baka, Gabor Kovacs, Micah Woodard, Shamishtaa Seshamani, Kevin Cao, Nathan Clack, Andrew Recknagel, Anna Grim, Pooja Balaram, Emily Turschak, Marcus Hooper, Alan Liddell, John Rohde, Ayana Hellevik, Kevin Takasaki, Lindsey Erion Barner, Molly Logsdon, Chris Chronopoulos, Saskia EJ de Vries, Jonathan T Ting, Steven Perlmutter, Brian E Kalmbach, Nikolai Dembrow, Bosiljka Tasic, R Clay Reid, David Feng, Karel Svoboda, Melike Lakadamyali, John R Huguenard

publication / 2025
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Cell Reports
Brain Science

Emily Kussick, Nelson Johansen, Naz Taskin, Ananya Chowdhury, Meagan A. Quinlan, Alex Fraser, Andrew G. Clark, Brooke Wynalda, Refugio Martinez, Erin L. Groce, Melissa Reding, Elizabeth Liang, Lyudmila Shulga, Cindy Huang, Tamara Casper, Michael Clark, Windy Ho, Yuan Gao, Cindy T. J. van Velthoven, Cassandra Sobieski, Rebecca Ferrer, Melissa R. Berg, Britni C. Curtis, Chris English, Jesse C. Day, Michal G. Fortuna, Nicholas Donadio, Dakota Newman, Shenqin Yao, Anish Bhaswanth Chakka, Jeff Goldy, Amy Torkelson, Junitta B. Guzman, Rushil Chakrabarty, Beagen Nguy, Nathan Guilford, Trangthanh H. Pham, Vonn Wright, Kara Ronellenfitch, Robyn Naidoo, Jaimie Kenney, Ali Williford, Charu Ramakrishnan, Antonia Drinnenberg, Kathryn Gudsnuk, Bargavi Thyagarajan, Kimberly A. Smith, Nick Dee, Karl Deisseroth, Hongkui Zeng, Zizhen Yao, Bosiljka Tasic, Boaz P. Levi, Rebecca Hodge, Trygve E. Bakken, Ed S. Lein, Jonathan T. Ting, Tanya L. Daigle

publication / 2025
Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex
Cell Genomics
Brain Science

Nelson J. Johansen, Niklas Kempynck, Nathan R. Zemke, Saroja Somasundaram, Seppe De Winter, Marcus Hooper, Deepanjali Dwivedi, Ruchi Lohia, Fabien Wehbe, Bocheng Li, Darina Abaffyová, Ethan J. Armand, Julie De Man, Eren Can Ekşi, Nikolai Hecker, Gert Hulselmans, Vasilis Konstantakos, David Mauduit, John K. Mich, Gabriele Partel, Tanya L. Daigle, Boaz P. Levi, Kai Zhang, Yoshiaki Tanaka, Jesse Gillis, Jonathan T. Ting, Yoav Ben-Simon, Jeremy Miller, Joseph R. Ecker, Bing Ren, Stein Aerts, Ed S. Lein, Bosiljka Tasic, Trygve E. Bakken

publication / 2025
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types
Cell
Brain Science
Cell Science

Yoav Ben-Simon, Marcus Hooper, Sujatha Narayan, Tanya L. Daigle, Deepanjali Dwivedi, Sharon W. Way, Aaron Oster, David A. Stafford, John K. Mich, Michael J. Taormina, Refugio A. Martinez, Ximena Opitz-Araya, Jada R. Roth, Jason R. Alexander, Shona Allen, Adam Amster, Joel Arbuckle, Angela Ayala, Pamela M. Baker, Trygve E. Bakken, Tyler Barcelli, Stuard Barta, Jacqueline Bendrick, Darren Bertagnolli, Cameron Bielstein, Prajal Bishwakarma, Jessica Bowlus, Gabriella Boyer, Krissy Brouner, Brittny Casian, Tamara Casper, Anish B. Chakka, Rushil Chakrabarty, Rebecca K. Chance, Sakshi Chavan, Michael Clark, Kaity Colbert, Forrest Collman, Scott Daniel, Maxwell Departee, Peter DiValentin, Nicholas Donadio, Nadezhda Dotson, Tom Egdorf, Tim Fliss, Mariano Gabitto, Jazmin Garcia, Amanda Gary, Molly Gasperini, Jessica Gloe, Jeff Goldy, Bryan B. Gore, Lucas Graybuck, Noah Greisman, Francoise Haeseleer, Carliana Halterman, Zeb Haradon, Samantha D. Hastings, Olivia Helback, Windy Ho, Dirk Hockemeyer, Cindy Huang, Sydney Huff, Avery Hunker, Nelson Johansen, Danielle Jones, Zoe Juneau, Brian Kalmbach, Madhav Kannan, Shannon Khem, Emily Kussick, Rana Kutsal, Rachael Larsen, Changkyu Lee, Angus Y. Lee, Madison Leibly, Garreck H. Lenz, Su Li, Elizabeth Liang, Nicholas Lusk, Zachary Madigan, Jessica Malloy, Jocelin Malone, Rachel McCue, Jose Melchor, Tyler Mollenkopf, Skyler Moosman, Elyse Morin, Dakota Newman, Lydia Ng, Kiet Ngo, Victoria Omstead, Sven Otto, Alana Oyama, Nick Pena, Trangthanh Pham, Elliot Phillips, Christina A. Pom, Lydia Potekhina, Shea Ransford, Patrick L. Ray, Dean Rette, Cade Reynoldson, Christine Rimorin, Dana Rocha, Augustin Ruiz, Raymond E. A. Sanchez, Lane Sawyer, Adriana Sedeno-Cortes, Joshua P. Sevigny, Nadiya Shapovalova, Noah Shepard, Lyudmila Shulga, Ana R. Sigler, La'Akea Siverts, Sherif Soliman, Saroja Somasundaram, Brian Staats, Kaiya Stewart, Eric Szelenyi, Michael Tieu, Cameron Trader, Alex Tran, Cindy T. J. van Velthoven, Miranda Walker, Yimin Wang, Natalie Weed, Morgan Wirthlin, Toren Wood, Brooke Wynalda, Zizhen Yao, Thomas Zhou, Jeanelle Ariza, Nick Dee, Melissa Reding, Kara Ronellenfitch, Shoaib Mufti, Susan M. Sunkin, Kimberly A. Smith, Luke Esposito, Jack Waters, Bargavi Thyagarajan, Shenqin Yao, Ed S. Lein, Hongkui Zeng, Boaz P. Levi, John Ngai, Jonathan T. Ting, Bosiljka Tasic

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