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people

Kimberly Smith

Director, Molecular Biology

teams /
Allenite

Kimberly Smith joined the Allen Institute in October 2003 as the first bench scientist, bringing with her over 7 years of experience overseeing large scale genomic and transcriptomics projects. Since joining the Institute, Kim’s focus has been on influencing, producing, and managing many of the most well-known Brain-map products. In particular, she has managed production groups, methods development, and data handling for six research atlases including the signature mouse brain atlas and mouse spinal cord atlas. Kim currently serves as the Director of Molecular Biology, directly managing the Single Cell RNASeq Core. The Molecular Biology department also includes the Histology, Genotyping, and Bioinformatics Core teams responsible for providing core resource services to all of Brain Science.

Kim’s first experiences with large scale genomics project management was working on Chromosome 7 of the Human Genome Project, the Pseudomonas Genome Project, and the Rice Genome Project, all while at the University of Washington. She then went on to manage and develop the lab operations of the Center for Expression Arrays at the University of Washington, branching out into the new Microarray technology at the time. After a few years at a new biotechnology venture that did not succeed, Kim welcomed the opportunity to start at the ground floor of the Allen Institute for Brain Science, employing her experience both at the bench and at establishing new production pipelines.

Kim received a B.S. in Cell and Molecular Biology from the University of Washington.

research focus

As the first bench scientist hired at Allen Institute for Brain Science, Kim has enjoyed being a part of the growth and development of the Institute since 2003. She is passionate about generating high quality datasets that have high impact on scientific understanding of our world. She enjoys developing new processes and production pipelines, focusing on data integrity and data quality, as the backbone to generating these datasets.

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Scientists complete first drafts of developing mammalian brain cell atlases
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Reflections on the beginnings of the Allen Institute
The Allen Institute houses some impressive statistics behind its glassy facade: more than 2.7 million high-resolution science images and nearly 1,400 hours of movies of brain activity shared with the global scientific community.

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featured publications

publication / 2025
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits
Neuron
publication / 2024
Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen
Cell Reports
publication / 2024
Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations
Cell Reports
publication / 2023
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Nature
publication / 2023
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Science (New York, N.Y.)
publication / 2023
Comparative transcriptomics reveals human-specific cortical features
Science (New York, N.Y.)
publication / 2023
Interindividual variation in human cortical cell type abundance and expression
Science (New York, N.Y.)
publication / 2023
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
Science (New York, N.Y.)
publication / 2023
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Science (New York, N.Y.)
publication / 2023
Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types
Nature Communications
publication / 2022
Local connectivity and synaptic dynamics in mouse and human neocortex
Science (New York, N.Y.)
publication / 2021
Human neocortical expansion involves glutamatergic neuron diversification
Nature
publication / 2021
Isoform cell-type specificity in the mouse primary motor cortex
Nature
publication / 2021
Comparative cellular analysis of motor cortex in human, marmoset and mouse
Nature
publication / 2021
A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex
Nature
publication / 2021
Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons
Neuron
publication / 2021
Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans
eLife
publication / 2021
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
Cell
publication / 2021
Enhancer viruses for combinatorial cell-subclass-specific labeling
Neuron
publication / 2021
Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network
Neuron
publication / 2020
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells
Cell
publication / 2016
Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Nature Neuroscience
publication / 2014
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain
Neuron
publication / 2012
Transcriptional architecture of the primate neocortex
Neuron
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