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people

Séverine Durand

Scientist III

teams /
Allenite

In her current role, Séverine manages the Neuropixels operations team involved in data collection for Openscope. Séverine joined the Allen Institute in 2012 as a scientist with Clay Reid exploring visual properties in V1 and dLGN during awakeness and anesthesia with electrophysiology. Séverine joined Shawn Olsen’s team in 2018 to develop and execute Neuropixels pipelines (passive and active behavior). Prior to joining the institute, Séverine received a PhD in Neurosciences from the University of Zurich with Matteo Carandini deciphering center-surround interactions in V1 receptive fields. She went on to postdocs in Tokyo (Riken) and Boston (Harvard University) with Takao Hensch, investigating the development of visual properties in Rett Syndrome model mice.

research focus

I have always been fascinated by how our brain masters the treatment of millions of cues in our everyday environment, and especially the amazing tasks performed by our visual system. How do cells communicate to each other, how do they integrate information, how can we understand neural coding, and what is the role of different cell types? I hope to be able to dissect some of these questions here at the Allen Institute by recording directly from structures such as V1 and LGN. I aim to provide large-scale high-quality data that will help to better understand the first stages of visual information processing.

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news
From 300,000 mouse neurons, scientists hope to glean how the brain drives behavior
New public dataset captures billions of electrical spikes from brains of animals trained to identify ‘oddball’ photos
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A day in the (neuroscience) life: OpenScope
Scientists on the OpenScope team help share the Allen Institute’s ‘observatory of the mind’ with the larger scientific community

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featured publications

preprint / 2025
Adaptation, not prediction, drives neuronal spiking responses in mammalian sensory cortex
publication / 2024
SHIELD: Skull-shaped hemispheric implants enabling large-scale electrophysiology datasets in the mouse brain
Neuron
preprint / 2024
Deciphering neuronal variability across states reveals dynamic sensory encoding
publication / 2023
Gaussian Partial Information Decomposition: Bias Correction and Application to High-dimensional Data
Advances in Neural Information Processing Systems
preprint / 2023
Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics
preprint / 2023
Recurrent pattern completion drives the neocortical representation of sensory inference
publication / 2023
Acute head-fixed recordings in awake mice with multiple Neuropixels probes
Nature Protocols
publication / 2022
Multi-regional module-based signal transmission in mouse visual cortex
Neuron
publication / 2021
Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology
eLife
publication / 2021
Survey of spiking in the mouse visual system reveals functional hierarchy
Nature
publication / 2018
Visual physiology of the layer 4 cortical circuit in silico
PLoS computational biology
publication / 2016
A Comparison of Visual Response Properties in the Lateral Geniculate Nucleus and Primary Visual Cortex of Awake and Anesthetized Mice
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience
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