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Allen Institute discoveries, innovations, and open-source resources are transforming the scientific landscape and making progress possible. Read on for the latest news and highlights.

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Brainy fun for all ages at BrainFest 2025

Mar 18, 2025

Thousands of visitors gathered to explore their amazing brains at the second annual BrainFest, a partnership of the Allen Institute and Pacific...

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spinal motor neurons in green and red

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SciShots: Lighting up neurons to combat ALS

Aug 14, 2024

Scientists have found a way to selectively target neurons damaged in spinal motor diseases.

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Black and white image of a fusion of silicone and human cells designed to mimic the heart’s mechanics.

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SciShots: A heart on a chip

Feb 14, 2024

Heart cells hit a tiny “gym” to help scientists screen for toxic cancer drugs

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Image of mouse lungs

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SciShots: A tree-like mouse lung

Aug 7, 2023

Scientists are learning the bartering system of two cell types to understand the lifecycle of a lung

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SciShots Blood Vessel

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SciShots: How to feed mini-organs

May 17, 2023

Scientists are making lab-grown mini-organs more lifelike by adding blood vessels

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An astrocyte from the striatum

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SciShots: Star-shaped brain cells linked to OCD

Apr 26, 2023

Mouse study finds disease-linked molecule influences the intricate, beautiful patterns of the brain cells known as astrocytes.

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Microscopic view of a macrophage with actin highlighted in red and antibody-coated beads in yellow

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SciShots: Tracking immune cells’ digestion

Apr 3, 2023

Scientists are watching cells swallow microscopic beads in the hopes of better understanding the autoimmune disorder rheumatoid arthritis 

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SciShots: Who talks to the visual part of the brain?

Dec 22, 2022

Technique built off rabies virus lets scientists trace backward flow of neural activity in the mouse brain

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A portion of the mouse brain in gray showing colorful red and blue dots in the cortex.

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SciShots: Illuminating a mysterious brain structure

Nov 11, 2022

Neuroscientists are shedding literal light on the mouse claustrum, a tiny part of the brain with an outsized number of connections

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SciShots: Brain-o-lantern

Oct 31, 2022

Quality control spies a spooky brain

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SciShots: The Brain’s Cleanup Crew and Paramedics

Oct 14, 2022

The shape-shifting microglia play a vital role in maintaining brain health

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SciShots: The brain’s mysterious, multipurpose immune system

Sep 16, 2022

Microglial cells act as the brain’s waste disposal when healthy — can they be manipulated to protect against disease?

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SciShots: Clusters of Alzheimer’s cells

Aug 5, 2022

New data explores the cellular landscape of Alzheimer’s disease

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Image of a glowing mouse brain

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SciShots: The 3D network inside a mouse’s brain

Jul 8, 2022

Scientists are piecing together the puzzle of the brain using light-sheet microscopy

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SciShots: Brain tumors in high-res

Jun 30, 2022

Scientists are using tumor “spheroids” to study glioblastoma, a deadly brain cancer

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SciShots: Exploring cellular variability

Jun 10, 2022

Scientists are studying the wide range of “normal” within human cells

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SciShots: Glowing muscles of the comb jelly

May 27, 2022

Biologists are studying the neurons and muscle cells of the ctenophore, a type of sea jelly that is the sister group to all other animals

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Four different kinds of brain cells are shown in high resolution. A large green neuron in the center is surrounded by different kinds of brain cells in purple, gold and pink.

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SciShots: A quartet of brain cells

May 20, 2022

Scientists are sifting through the hundreds of thousands of brain cells present in a cubic millimeter of mouse brain

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SciShots: The labyrinthian protein factory of the cell

May 6, 2022

Graphics software for microscope imagery lights up the endoplasmic reticulum

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SciShots: How the brain plugs leaks

Apr 22, 2022

A delicate molecular dance maintains the blood-brain barrier, protecting the brain while allowing transport of necessary resources

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