Solving the mysteries of bioscience
Foundational Science Fuels Breakthroughs
Inspiring Next-Generation Scientists
Characterizing and mapping brain cell types with unprecedented precision and scale.
Goals and Approach
How many brain cell types are there? What is their form, function, and how do they connect? Teams at the Allen Institute for Brain Science are working to answer these foundational neuroscience questions. By cataloguing and genetically profiling cell types of the brain with incredible precision and detail, we are working to improve our fundamental understanding of brain development, evolution, and disease.
Using a team science approach, we are exploring the mammalian brain at a molecular level and sharing our insights with the world. We do this through advanced single-cell molecular analysis techniques, such as single-cell RNA sequencing and electrophysiology, combined with cutting-edge imaging technologies that provide a comprehensive view of how our brains are organized; what their cellular makeup is; how those cells connect, develop, and function; and the complex relationship between these factors.
Meet our teams
Brain Science Data Tools & Research Highlights
We’re defining and analyzing the different cells that make up the mammalian brain to better understand how our brains work, how they develop, and what goes wrong in disease. Using a big, team, and open science approach, we share our discoveries, data, and resources with the broader scientific community to catalyze breakthroughs.
Facilitating the integration of best practices in scientific research and development with innovative business approaches to further accelerate operational efficiency
Driving breakthroughs in neuroscience through advanced computation, data management technologies and collaborative open data sharing
Meet the team
Establishing connections between morphoelectric characteristics and transcriptomic-defined cell types
Characterizing cellular diversity in the nervous system of humans and other mammals to study disease, evolution and brain function.
Exploring the diversity of cell types in the brain using a variety of microscopy and image processing techniques.
Leading an effort toward comprehensive molecular analysis of cell type identity in the mouse brain and building state-of-the-art transgenic and viral tools to experimentally access those cell types.
Investigating the cellular and circuit mechanisms underlying changes in cortical physiology with behavior.
Investigating the neuroanatomical architecture of the brain at the population and single cell level.
MEET THE TEAM
Ed Lein, Ph.D.
Senior Investigator, Allen Institute for Brain Science
Learn more about our other Scientific Programs.
The Allen Institute for Cell Science is focused on exploring and understanding human cells — the incredibly complex building blocks of our bodies.
The Allen Institute for Immunology works to understand the delicate balancing act of the human immune system—how it works when we’re healthy, and what goes wrong in disease.