A Bayesian framework for the detection of diffusive heterogeneity

05.07.2020

Cells are crowded and spatially heterogeneous, complicating the transport of organelles, proteins and other substrates. One aspect of this complex...

CellProfiler 3.0: Next-generation image processing for biology

07.03.2018

CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we...

A deep generative model of 3D single-cell organization

01.18.2022

We introduce a framework for end-to-end integrative modeling of 3D single-cell multi-channel fluorescent image data of diverse subcellular structures....

Similar Odor Discrimination Behavior in Head-Restrained and Freely Moving Mice

12.18.2012

A major challenge in neuroscience is relating neuronal activity to animal behavior. In olfaction limited techniques are available for these...

A gut-to-brain signal of fluid osmolarity controls thirst satiation

4/2019

Optimal foraging, the marginal value theorem

4/1976

Neural population dynamics of computing with synaptic modulations

02.23.2023

In addition to long-timescale rewiring, synapses in the brain are subject to significant modulation that occurs at faster timescales. These...

On the Role of Theory and Modeling in Neuroscience

02.15.2023

In recent years, the field of neuroscience has gone through rapid experimental advances and a significant increase in the use of quantitative and...

Heterogeneity in Neuronal Dynamics Is Learned by Gradient Descent for Temporal Processing Tasks

02.13.2023

Individual neurons in the brain have complex intrinsic dynamics that are highly diverse. We hypothesize that the complex dynamics produced by networks...

Regional and cell-type-specific afferent and efferent projections of the mouse claustrum

02.11.2023

The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. Its regional anatomy and...

Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn

02.08.2023

Spinally-projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on...

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease

02.02.2023

Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However,...

Acute head-fixed recordings in awake mice with multiple Neuropixels probes

02.01.2023

Multi-electrode arrays such as Neuropixels probes enable electrophysiological recordings from large populations of single neurons with high temporal...

Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels

02.01.2023

Patients with Fragile X syndrome, the leading monogenetic cause of autism, suffer from impairments related to the prefrontal cortex, including working...

A whole-brain monosynaptic input connectome to neuron classes in mouse visual cortex

02.01.2023

Identification of structural connections between neurons is a prerequisite to understanding brain function. Here we developed a pipeline to...

Spatial transcriptomics for profiling the tropism of viral vectors in tissues

01.26.2023

A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision access to cell subtypes is a lack of high-throughput,...

Brain Data Standards – A method for building data-driven cell-type ontologies

01.24.2023

Large-scale single-cell 'omics profiling is being used to define a complete catalogue of brain cell types, something that traditional methods struggle...

Influence of claustrum on cortex varies by area, layer, and cell type

01.18.2023

The claustrum is a small subcortical structure with widespread connections to disparate regions of the cortex. However, the impact of the claustrum on...

Neural assemblies uncovered by generative modeling explain whole-brain activity statistics and reflect structural connectivity

01.17.2023

Patterns of endogenous activity in the brain reflect a stochastic exploration of the neuronal state space that is constrained by the underlying...

Smart genetically-encoded biosensors for the chemical monitoring of living systems

01.12.2023

Genetically-encoded biosensors provide the all-optical and non-invasive visualization of dynamic biochemical events within living systems, which has...