Solving the mysteries of bioscience
We are an independent nonprofit bioscience research institute aimed at unlocking the mysteries of human biology through foundational science.
Foundational Science Fuels Breakthroughs
We are leaders in large-scale research that transforms our understanding of human health and disease and shapes how science is conducted worldwide.
Inspiring Next-Generation Scientists
To us, open science extends to inspiring the next generation of scientists by supporting access to science resources, research, and experiences.
Explore publications from the Allen Institute.
11.11.2021
Deep immune profiling is essential for understanding the human immune system in health and disease.
05.07.2020
Cells are crowded and spatially heterogeneous, complicating the transport of organelles, proteins and other substrates. One aspect of this complex...
03.27.2023
Longitudinal bulk and single-cell omics data is increasingly generated for biological and clinical research but is challenging to analyze due to its...
03.27.2022
Barcode-based multiplexing methods can be used to increase throughput and reduce batch effects in large single-cell genomics studies.
07.03.2018
CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we...
01.18.2022
We introduce a framework for end-to-end integrative modeling of 3D single-cell multi-channel fluorescent image data of diverse subcellular structures....
12.18.2012
A major challenge in neuroscience is relating neuronal activity to animal behavior. In olfaction limited techniques are available for these...
04.09.2021
Single-cell measurements of cellular characteristics have been instrumental in understanding the heterogeneous pathways that drive differentiation,...
04.15.2021
Multi-omic profiling of human peripheral blood is increasingly utilized to identify biomarkers and pathophysiologic mechanisms of disease. The...
04.12.2023
A prominent trend in single-cell transcriptomics is providing spatial context alongside a characterization of each cell's molecular state. This...
04.08.2023
Early reemergence of consciousness predicts long-term functional recovery for patients with severe brain injury. However, tools to reliably detect...
03.30.2023
Focal epileptic seizures are characterized by abnormal neuronal discharges that can spread to other cortical areas and interfere with brain activity,...
03.28.2023
The ability to optically image cellular transmembrane voltages at millisecond-timescale resolutions can offer unprecedented insight into the function...
02.23.2023
In addition to long-timescale rewiring, synapses in the brain are subject to significant modulation that occurs at faster timescales. These...
02.15.2023
In recent years, the field of neuroscience has gone through rapid experimental advances and a significant increase in the use of quantitative and...
02.13.2023
Individual neurons in the brain have complex intrinsic dynamics that are highly diverse. We hypothesize that the complex dynamics produced by networks...
02.11.2023
The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. Its regional anatomy and...
02.08.2023
Spinally-projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on...
02.02.2023
Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However,...
02.01.2023
Multi-electrode arrays such as Neuropixels probes enable electrophysiological recordings from large populations of single neurons with high temporal...
