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Explore publications from the Allen Institute.
05.07.2020
Cells are crowded and spatially heterogeneous, complicating the transport of organelles, proteins and other substrates. One aspect of this complex...
07.03.2018
CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we...
01.18.2022
We introduce a framework for end-to-end integrative modeling of 3D single-cell multi-channel fluorescent image data of diverse subcellular structures....
12.18.2012
A major challenge in neuroscience is relating neuronal activity to animal behavior. In olfaction limited techniques are available for these...
4/2019
4/1976
02.23.2023
In addition to long-timescale rewiring, synapses in the brain are subject to significant modulation that occurs at faster timescales. These...
02.15.2023
In recent years, the field of neuroscience has gone through rapid experimental advances and a significant increase in the use of quantitative and...
02.13.2023
Individual neurons in the brain have complex intrinsic dynamics that are highly diverse. We hypothesize that the complex dynamics produced by networks...
02.11.2023
The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. Its regional anatomy and...
02.08.2023
Spinally-projecting serotonergic neurons play a key role in controlling pain sensitivity and can either increase or decrease nociception depending on...
02.02.2023
Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However,...
02.01.2023
Multi-electrode arrays such as Neuropixels probes enable electrophysiological recordings from large populations of single neurons with high temporal...
Patients with Fragile X syndrome, the leading monogenetic cause of autism, suffer from impairments related to the prefrontal cortex, including working...
Identification of structural connections between neurons is a prerequisite to understanding brain function. Here we developed a pipeline to...
01.26.2023
A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision access to cell subtypes is a lack of high-throughput,...
01.24.2023
Large-scale single-cell 'omics profiling is being used to define a complete catalogue of brain cell types, something that traditional methods struggle...
01.18.2023
The claustrum is a small subcortical structure with widespread connections to disparate regions of the cortex. However, the impact of the claustrum on...
01.17.2023
Patterns of endogenous activity in the brain reflect a stochastic exploration of the neuronal state space that is constrained by the underlying...
01.12.2023
Genetically-encoded biosensors provide the all-optical and non-invasive visualization of dynamic biochemical events within living systems, which has...