Solving the mysteries of bioscience
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Bio:
Research Focus:
The brain contains a seemingly endless number of neuron types, yet all neurons perform a similar transformation of synaptic input arriving at the dendrite into action potentials initiated at the axon. The details of this transformation vary across cell types and are crucial in determining the function of a given neuron in its circuit. I use patch-clamp recordings from the soma and dendrite to investigate how the unique morphology, synaptic and intrinsic properties of different cell types shape a neuron’s input/output transformation. In collaboration with Seattle area neurosurgeons, I am participating in a project at the Allen Institute to extend this analysis to human cerebral cortex. Our goal is to use a combined analysis of gene expression, physiology and morphology to create a comprehensive taxonomy of cell types in human temporal cortex.
Expertise
Research Programs
12.27.2022
08.09.2022
10.01.2021