Solving the mysteries of bioscience
We are an independent nonprofit bioscience research institute aimed at unlocking the mysteries of human biology through foundational science.
Foundational Science Fuels Breakthroughs
We are leaders in large-scale research that transforms our understanding of human health and disease and shapes how science is conducted worldwide.
Inspiring Next-Generation Scientists
To us, open science extends to inspiring the next generation of scientists by supporting access to science resources, research, and experiences.
The brain contains a seemingly endless number of neuron types, yet all neurons perform a similar transformation of synaptic input arriving at the dendrite into action potentials initiated at the axon. The details of this transformation vary across cell types and are crucial in determining the function of a given neuron in its circuit. I use patch-clamp recordings from the soma and dendrite to investigate how the unique morphology, synaptic and intrinsic properties of different cell types shape a neuron’s input/output transformation. In collaboration with Seattle area neurosurgeons, I am participating in a project at the Allen Institute to extend this analysis to human cerebral cortex. Our goal is to use a combined analysis of gene expression, physiology and morphology to create a comprehensive taxonomy of cell types in human temporal cortex.