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stories from the front lines of discovery
From scientific breakthroughs to new open‑source tools, the Allen Institute’s work is reshaping how science is done—and who it’s for. Explore the latest news, stories, and highlights from across our research, partnerships, and open science efforts.
AI BioDesign accelerator combines experimental biology and artificial intelligence to learn nature’s design rules
Researchers from the Allen Institute, University of Washington, and Fred Hutch Cancer Center, supported by Fund for Science and Technology, will build open AI models, datasets, and tools to accelerate biological design for health, sustainability, and other global challenges

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A day in the (neuroscience) life: Tissue Processing
The researchers in this lab prepare brain tissue for several other teams at the Allen Institute
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SciShots: a sneak peek of a new Alzheimer’s disease project
Researchers are in the early stages of investigating the brain cells most vulnerable to this devastating form of dementia
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How do our neurons connect? New study probes the details of human and mouse synapses
‘Multipatch’ technique catalogs more than 1700 connections between neurons in publicly released dataset
brain science
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SciShots: neurons in crisp, clear detail
Electron microscopy reveals the stunning 3D shapes of mouse visual neurons
brain science
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SciShots: a crown of neurons
Brain-wide neuron tracing of cells in the mouse claustrum, a mysterious structure that’s highly connected to the rest of the brain
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SciShots: a neuron’s love connection
A specialized team of neuroscientists at the Allen Institute spend their days painstakingly tracing neurons’ complex branching structures
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A map of all our brains’ blood vessel cells finds new clues to Alzheimer’s disease
Scientists release the first cell-by-cell atlas of the human blood-brain barrier.
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SciShots: a cell’s fate
Synthetic biology is helping scientists understand development
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The Paul G. Allen Frontiers Group announces 23 new Allen Distinguished Investigators
$15.5M in research funding will support cutting-edge projects in mammalian synthetic biology, the neuroscience of under-studied animals, and tiny...
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SciShots: cellular scaffolding
Computer animation techniques light up cells’ inner workings
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Seattle scientists launch $95 million AI biology effort
The Allen Institute, University of Washington, and Fred Hutch Cancer Center are launching a $95 million effort to use AI to design biology that doesn’t exist in nature. Called AI BioDesign and led scientifically by Nobel laureate David Baker and genome scientist Jay Shendure, the initiative will use AI models to propose new DNA sequences and biological molecules.

AI learns nature’s code: Allen Institute, UW and Fred Hutch launch $95M open science initiative
Three of Seattle’s top scientific institutions are launching a nearly $95 million research initiative that will generate data and train AI models to design proteins and genes that don’t exist in nature — sharing the results freely to help others develop new medicines and materials.

‘It’s going to come quicker than we think’: Parkinson’s advocate shares hope for treatment as Allen Institute launches AI-powered initiative
The institute has launched the Brain Health Accelerator, an international collaboration involving about 30 research organizations that will use artificial intelligence, human brain tissue and advanced cellular mapping to better understand diseases including Parkinson’s, Alzheimer’s disease, ALS, Huntington’s disease and Lewy body dementia.
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