The Shendure Lab

The Shendure Lab is part of the Howard Hughes Medical Institute and the University of Washington’s Department of Genome Sciences. This team is working to develop and apply new technologies and methods for genetics, genomics and molecular biology. Research by the Shendure Lab focuses on next-generation DNA sequencing to measure biological phenomena.

The Trapnell Lab

The Trapnell Lab at the University of Washington’s Department of Genome Sciences studies how genomes encode the program of vertebrate development and how that program goes awry in disease. They build new tools, technologies, and software for decoding this program from large-scale single-cell experiments.

The Pepper Lab

In the Pepper Lab, researchers study how cells of the adaptive immune system, called CD4+ T cells and B cells, form immunological memory by visualizing their differentiation, retention and function in both mice and humans. They accomplish this by using novel tetramer-based enrichment strategies to study small populations of antigen specific CD4+ T and B cells in both complex infectious diseases such as malaria as well as during allergic asthma using a house dust mite model. They additionally use transgenic mice with various genetic ablations to interrogate the underlying molecular mechanisms involved in memory cell development and function.

Allen Institute Team

The research team at Allen Institute is building cellular recording systems using technologies developed by researchers in the Shendure lab at UW Medicine. These technologies have the potential to record information to the genomes of cells at the scale of the whole organism.