Team

Staff Profiles

Associate Investigator

Saskia de Vries joined the Allen Institute in 2012 as a scientist in the neural coding team. With a background in systems neuroscience, she has studied visual processing in both vertebrate and invertebrate systems using a combination of physiological, computational, behavioral and molecular tools to parse how neural circuits process visual information and use that information to select appropriate behavior. Prior to joining the Allen Institute, de Vries was a postdoctoral scholar in the department of neurobiology at Stanford University, where she identified loom sensitive neurons in the optic lobe of the fruit fly and directly linked them to the fly's escape behavior. De Vries received a B.S. from Yale University in molecular biophysics and biochemistry and a Ph.D. in neurobiology from Harvard University.

Research Interests

Research Interests My research interests are centered on how the brain transforms sensory information into perceptions and appropriate behaviors. Such transformations result from sophisticated computations that are carried out by individual neurons and their interactions within a larger circuit. I seek to understand the cellular and circuit mechanisms that underpin these computations. My research combines optical imaging with computational, behavioral and molecular tools to examine how individual cells function in the visual circuit.

Expertise

Neural circuits
Systems neuroscience
Visual neuroscience
Electrophysiology

Research Programs

Neural coding

Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

eLife
March 8, 2021

Huang L, Ledochowitsch P, Knoblich U, Lecoq J, Murphy GJ, Reid RC, de Vries SEJ, Koch C, Zeng H, Buice MA, Waters J, Li L

The effect of inclusion criteria on the functional properties reported in mouse visual cortex

eNeuro
January 28, 2021

Mesa N, Waters J, de Vries SEJ.

Survey of spiking in the mouse visual system reveals functional hierarchy

Nature
January 20, 2021

Siegle JH, Jia X, Durand S, Gale S, Bennett C, Graddis N, Heller G, Ramirez TK, Choi H, Luviano JA, Groblewski PA, Ahmed R, Arkhipov A, Bernard A, Billeh YN, Brown D, Buice MA, Cain N, Caldejon S, Casal L, Cho A, Chvilicek M, Cox TC, Dai K, Denman DJ, de Vries S., Dietzman R, Esposito L, Farrell C, Feng D, Galbraith J, Garrett M, Gelfand EC, Hancock N, Harris JA, Howard R, Hu B, Hytnen R, Iyer R, Jessett E, Johnson K, Kato I, Kiggins J, Lambert S, Lecoq J, Ledochowitsch P, Lee JH, Leon A, Li Y, Liang E, Long F, Mace K, Melchior J, Millman D, Mollenkopf T, Nayan C, Ng L, Ngo D, Nguyen T, Nicovich PR, North K, Ocker GK, Ollerenshaw D, Oliver M, Pachitariu M, Perkins J, Reding M, Reid D, Robertson M, Ronellenfitch K, Seid S, Slaughterbeck C, Stoecklin M, Sullivan D, Sutton B, Swapp J, Thompson C, Turner K, Wakeman W, Whitesell JD, Williams D, Williford A, Young R, Zeng H, Naylor S, Phillips JW, Reid RC, Mihalas S, Olsen SR, Koch C

A standardized head-fixation system for performing large-scale, in vivo physiological recordings in mice

Journal of Neuroscience Methods
September 15, 2020

Groblewski PA, Sullivan D, Lecoq J, de Vries SEJ, Caldejon S, L'Heureux Q, Keenan T, Roll K, Slaughterback C, Williford A, Farrell C

Recognizing Team Science Contributions in Academic Hiring, Promotion, and Tenure

Journal of Neuroscience
August 26, 2020

Cline H, Coolen L, de Vries S, Hyman S, Segal R, Steward O

VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli

eLife
October 27, 2020

Millman DJ, Ocker GK, Caldejon S, Kato I, Larkin JD, Lee EK, Luviano J, Nayan C, Nguyen TV, North K, Seid S, White C, Lecoq J, Reid C, Buice MA, de Vries SE

Aberration-free multi-plane imaging of neural activity from the mammalian brain using a fast-switching liquid crystal spatial light modulator

Biomed Opt Express
September 11, 2019

Liu R, Ball N, Brockill J, Kuan L, Millman D, White C, Leon A, Williams D, Nishiwaki S, de Vries S, Larkin J, Sullivan D, Slaughterbeck C, Farrell C, Saggau P

A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex

Nature Neuroscience
December 16, 2019

de Vries S, Lecoq J, Buice MA, Groblewski PA, Ocker GK, Oliver M, Feng F, Cain N, Ledochowitsch P, Millman D, Roll K, Garrett M, Keenan T, Kuan L, Mihalas S, Olsen S, Thompson C, Wakeman W, Waters J, Williams D, Barber C, Berbesque N, Blanchard B, Bowles N, Caldejon S, Casal L, Cho A, Cross S, Dang C, Dolbeare T, Edwards M, Galbraith J, Gaudreault N, Griffin F, Hargrave P, Howard R, Huang L, Jewell S, Keller N, Knoblich U, Larkin J, Larsen R, Lau C, Lee E, Lee F, Leon A, Li L, Long F, Luviano J, Mace K, Nguyen T, Perkins J, Robertson M, Seid S, Shea-Brown E, Shi J, Sjoquist N, Slaughterbeck C, Sullivan D, Valenza R, White C, Williford A, Witten D, Zhuang J, Zeng H, Farrell C, Ng L, Bernard A, Phillips JW, R Reid C, Koch C

Visual physiology of the Layer 4 cortical circuit in silico

PLoS Computational Biology
November 12, 2018

Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-LLavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C

Optogenetic stimulation of escape behavior in Drosophila melanogaster

Journal of Visualized Experiments
January 2013

de Vries SEJ & Clandinin TR

Loom-sensitive neurons link computation to action in the Drosophila visual system

Current Biology
March 2012

de Vries SEJ & Clandinin TR

The projective field of a retinal amacrine cell

Journal of Neuroscience
June 2011

de Vries SEJ, Baccus SA, Meister M

Watching the fly brain in action

Nature Methods
July 2010

Clark DA, de Vries SEJ, Clandinin TR