Solving the mysteries of bioscience
Foundational Science Fuels Breakthroughs
Inspiring Next-Generation Scientists
As part of the Human Cell Types group, I will map human brain development by systematically identifying all the cell types that arise, and then charting the lineal relationships among those cell types. To facilitate this human lineage map, I am adapting flow cytometry techniques I developed in mouse brain to the human brain, using both authentic human samples as well as in vitro models of human development. New cell types will be discovered by unbiased antigen screening, systematically interrogated for gene expression profiles with single-cell transcriptomics, and then assembled into a lineage map. These data will be essential toward a complete understanding of how the human brain’s incredible diversity is achieved.