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Darrell Kotton, Ph.D.

Boston Medical Center/Boston University Center for Regenerative Medicine


Dr. Darrell Kotton is the founding Director of the Boston Medical Center/Boston University Center for Regenerative Medicine and oversees program development while coordinating the efforts of six physically-contiguous laboratories in their efforts to understand basic reprogramming mechanisms as well as approaches to the directed differentiation of pluripotent stem cells, following lessons from developmental biology to derive a variety of cell lineages for basic studies and disease models.

Dr. Darrell Kotton’s laboratory specializes in stem cell biology with a focus on applying stem cells to model and understand lung development and disease. He has trained graduate students and post-doctoral fellows who have gone on to become faculty members in academic medicine, laboratory PI’s, and industry scientists. In his role as an educator, he serves as the PI of the Boston University CTSI’s TL1 training grant in regenerative medicine. Dr. Kotton’s laboratory research has focused primarily on applying mouse and human pluripotent stem cells to investigate the developmental biology of endoderm and the biology of lung injury and repair. His group has developed reprogramming methods, endodermal differentiation protocols for pluripotent stem cells, and gene transfer methods to modulate stem cells or various resident lung cells for durable in vitro and in vivo gene expression. Most recently his laboratory has developed new approaches for generating lung and thyroid lineages from mouse or human pluripotent stem cells in vitro.

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