Brain Health accelerator to transform our understanding of brain disorders and develop new treatments
The global collaborative research initiative will initially target Alzheimer’s, Parkinson’s, Huntington’s disease, ALS, and Lewy body dementia
news
scientists fix genetic defect in mice tied to brain disorders that include autism and epilepsy
Gene therapy successfully reduced epileptic activity, hyperactivity and risk-taking behaviors tied to SYNGAP1-related disorders
news
Scientists can now target the cells at the center of ALS
For the first time ever, scientists have developed a precise genetic toolkit that can target the exact nerve cells destroyed by ALS-a discovery that...
featured media
media / Technology Networks
Alzheimer’s Memory Deficits Traced to Disrupted Brain Rhythms
Restoring a key protein may help brain cells regain the rhythms linked to memory and cognition.
featured publications
publication / 2014
CORTECON: a temporal transcriptome analysis of in vitro human cerebral cortex development from human embryonic stem cells
Neuron
publication / 2016
Fixed single-cell transcriptomic characterization of human radial glial diversity
Nature Methods
publication / 2016
Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Nature Neuroscience
publication / 2017
A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development
Cell Stem Cell
publication / 2017
Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation
Neuron
publication / 2017
Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states
eLife
publication / 2017
Putting Two Heads Together to Build a Better Brain
Cell Stem Cell
publication / 2018
Shared and distinct transcriptomic cell types across neocortical areas
Nature
publication / 2019
Conserved cell types with divergent features in human versus mouse cortex
Nature
publication / 2021
Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network
Neuron
publication / 2021
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
Cell Reports
publication / 2021
Enhancer viruses for combinatorial cell-subclass-specific labeling
Neuron
publication / 2021
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
Cell
publication / 2021
Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans
eLife
publication / 2021
Human neocortical expansion involves glutamatergic neuron diversification
Nature
publication / 2022
Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons
Nature Communications
publication / 2023
Linking connectome with transcriptome using a self-inactivating rabies virus
Nature Methods
publication / 2023
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Nature Communications
publication / 2023
Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
eLife
publication / 2023
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Nature Nanotechnology
publication / 2023
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
Science (New York, N.Y.)
publication / 2023
Interindividual variation in human cortical cell type abundance and expression
Science (New York, N.Y.)
publication / 2023
A comparative atlas of single-cell chromatin accessibility in the human brain
Science (New York, N.Y.)
publication / 2023
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Science (New York, N.Y.)
publication / 2023
Single-cell DNA methylation and 3D genome architecture in the human brain
Science (New York, N.Y.)
publication / 2023
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Nature
publication / 2024
Integrated multimodal cell atlas of Alzheimer's disease
Nature Neuroscience
publication / 2025
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
Nature
publication / 2025
A versatile cell line for establishing potency of cell type-specific AAV transgenes
Molecular Therapy. Methods & Clinical Development
publication / 2025
Integrating multimodal data to understand cortical circuit architecture and function
Nature Neuroscience
publication / 2025
Interneuron-specific dual-AAV SCN1A gene replacement corrects epileptic phenotypes in mouse models of Dravet syndrome
Science Translational Medicine
publication / 2025
AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders
Molecular Therapy: The Journal of the American Society of Gene Therapy
publication / 2025
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types
Cell
publication / 2025
Enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits
Neuron
publication / 2025
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Cell Reports
publication / 2025
Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex
Cell Genomics
publication / 2025
AAV-PHP.eB achieves superior neuronal transduction over AAV9 in pigtail macaques following intracerebroventricular administration
Molecular Therapy. Methods & Clinical Development
publication / 2026
Technical and biological sources of noise confound multiplexed enhancer AAV screening
Nature Communications
publication / 2026
Pool-packaged AAV libraries exhibit extensive length-dependent and homology-dependent chimerism
Nature Biotechnology
publication / 2026
Single-cell atlas of the developing Down syndrome brain cortex
