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stories from the front lines of discovery
From scientific breakthroughs to new open‑source tools, the Allen Institute’s work is reshaping how science is done—and who it’s for. Explore the latest news, stories, and highlights from across our research, partnerships, and open science efforts.
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AI BioDesign accelerator combines experimental biology and artificial intelligence to learn nature’s design rules

Researchers from the Allen Institute, University of Washington, and Fred Hutch Cancer Center, supported by Fund for Science and Technology, will build open AI models, datasets, and tools to accelerate biological design for health, sustainability, and other global challenges
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Data Stories | How a weight loss drug acts on the brain
Scientists at a pharmaceutical company want to know how the drug they developed for weight management affects the brain. Allen Institute resources are...
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A computational challenge to help developmental biology
Q&A with the scientists and organizers behind a new competition to use machine learning to reconstruct an entire animal’s developmental lineage
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Three collaborative studies launch on ‘OpenScope,’ a shared observatory for neuroscience
2019 projects will tackle Alzheimer’s disease, motion detection, and how the brain processes contextual information
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Allen Cell Methods: Cryopreservation of clonal human iPS cell lines in 96-well plates
To ensure researchers have success working with human induced pluripotent stem cell lines from the Allen Cell Catalog, Amanda Haupt, a research...
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How the gut keeps time - and keeps us healthy
New study identifies brain-intestine circadian signals that could underlie health problems related to night shift work and poor sleep
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Highest-Resolution Human Brain 'Parts List' To Date Lays Road Map to Better Treatments for Neurological and Psychiatric Disorders
Crucial differences discovered in human and mice brain cells could explain why many drugs that work in the lab don’t work in us
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This is what it’s like to donate your brain to science
Casey Schorr underwent invasive surgery to quell the epileptic seizures that were taking over his life. Now, a small piece of his brain tissue is...
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Virtual reality is helping neuroscientists better understand the brain
When Elise Shen goes to work, her morning starts much like that of anyone else with a desk job. She greets her coworkers. She fetches a cup of coffee....
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Simulations of life - in health and disease
Across many areas of biology, researchers are turning to virtual simulations to help ask and answer important questions.
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Machine learning toolkit lets biologists navigate their way through a 3D cell
In the world of computer vision, engineers need to build software that can recognize parts of an image or 3D visual field. Think, for example, a...
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These neurons are tied to one of multiple sclerosis’ most dramatic effects: Brain shrinkage
Multiple sclerosis begins with a maddening back and forth.
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Advancing Leading Edge Cancer Research in a $4.5 Million Collaboration
LLS, The Mark Foundation for Cancer Research and The Paul G. Allen Frontiers Group Join Forces to Advance Leading Edge Cancer Research
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media / Quanta Magazine
See Inside Cells Like Never Before in These Vivid Microscopic Images
Winning entries in the 2026 Nikon Small World competitions reveal the hidden interactions that govern everyday life.
media / Technology Networks
Alzheimer’s Memory Deficits Traced to Disrupted Brain Rhythms
Restoring a key protein may help brain cells regain the rhythms linked to memory and cognition.
media / TheScientist
A Molecular Typewriter Maps Cell Lineages in Mice
By stamping barcodes into the genome, researchers traced cell lineages from a single starting cell to more than 1.2 million cells in a developing mouse embryo.
media / The Brighter Side of News
Scientists construct a ‘family tree’ containing 1.28 million cells from a single embryo
A molecular recorder traces 1.28 million cells in one mouse embryo, revealing developmental patterns while covering about 10% of its cells.
media / BBC Radio (NewsDay)
Scientists create largest cellular lineage tree in a mammal
The findings can help us better understand developmental diseases and cancer
media / Yahoo News
70cm axon, 35,000 neurons, 400,000 cells: Researchers map brain’s ‘blue place'
Scientists have mapped the locus coeruleus in unprecedented detail, revealing that it operates like a targeted postal network rather than a loudspeaker, sending norepinephrine to specific brain regions.
media / New York Times
These Mice Have Partly Human Brains
The animals may help reveal the causes of brain disease in people and point the way to treatments. But researchers already are calling for new ethical guidelines.
media / WIRED
He Won the Nobel Prize for Protein Design
David Baker spoke with WIRED en Español about where biological design is headed next and the great potential and risks of taking biology outside the bounds of the natural world.
media / KUOW FM
Seattle research organizations team up to tackle AI biology
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