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Initial installment of data and tools will be expanded and enhanced in a series of future releases
4 min read
The Allen Institute for Brain Science announced today that it has launched the Allen Human Brain Atlas, a publicly available online atlas charting genes at work throughout the human brain. The data provided in this initial data release represent the most extensive and detailed body of information about gene activity in the human brain to date, documenting which genes are expressed, or “turned on” where. In the coming years, the Atlas will be expanded with more data and more sophisticated search, analysis and visualization tools to create a comprehensive resource useful to an increasingly wide range of scientists and research programs worldwide.
The Allen Human Brain Atlas, available at www.brain-map.org, is a unique multi-modal atlas of the human brain that integrates anatomic and genomic information to create a searchable, three-dimensional map of gene activity in the brain. Data modalities in this resource include magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and histology—providing information about gross neuroanatomy, pathways of neural connections, and microscopic anatomy, respectively—as well as gene expression data derived from multiple approaches.
“The launch of the Allen Human Brain Atlas is a significant milestone for the Allen Institute,” said Allan Jones, Ph.D., chief executive officer of the Allen Institute. “This is the largest and most challenging project we have undertaken to date, and after over two years of planning and nine months of data generation, we are delighted to now be able to get this first, significant dataset into the hands of the research community.”
The data in this inaugural release provide both a broad survey of gene activity throughout the entire adult human brain using microarrays, in which the entire genome can be analyzed in a single experiment, as well as more focused cellular-resolution analyses of the expression of individual genes in specific brain regions using in situ hybridization (ISH), a technique that provides images of where genes are expressed at high microscopic resolution and that was used for all earlier Allen Brain Atlas resources.
New data in this release include:
In addition, existing data from what was previously available as the Allen Human Cortex Study have now been integrated into the Allen Human Brain Atlas. These data include:
The Allen Human Brain Atlas is made possible through the Allen Institute’s unique funding model designed to transform public, private and foundation funds into open community resources that fuel a diversity of breakthrough scientific discoveries. To date, the following contributors have generously contributed financial support for the Atlas: philanthropist Paul G. Allen; Lee and Jeanne Zehrer; Mr. and Mrs. Richard Daly, Mr. and Mrs. Peter Eschenbach, Mr. William E. Fay, Jr., Mr. Nathan Hansen, Mr. and Mrs. Richard Jernstedt, Bruce and Kathryn Johnson, Mr. and Mrs. Martin Koldyke, Michael and Suzanne Moskow, Bruce and Gwill Newman, Mr. and Mrs. Peter Pond, Anonymous Donor (Board Members, Brain Research Foundation); Mr. and Mrs. James N. Bayer, Jr.; Mr. and Mrs. Richard L. Joutras; and Mr. and Mrs. Robert Lorch. Additional support of $471,240 covering just under 1% of the entire $55 million Allen Human Brain Atlas project is provided by Department of Health and Human Services Health Resources and Services Administration Award 1 C76HF15069-01-00.