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Woman reading book

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Hundreds of small molecules known as neuromodulators might influence how we learn

Dec 17, 2021

New models that capture how the brain retains information could also improve machine learning

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Rui Costa - President and CEO

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Allen Institute announces Rui Costa as next President and Chief Executive Officer

Dec 16, 2021

The Allen Institute today named Rui Costa, D.V.M., Ph.D., as its next president and chief executive officer.

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Researcher in protective suit

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$20M awards fund centers’ studies of human brain evolution, animal development

Dec 2, 2021

Two Allen Discovery Centers enter their next phase of discovery, poised to address large questions about biology

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2021 Next Generation Leaders

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Allen Institute announces 2021 Next Generation Leaders

Nov 8, 2021

Six early-career neuroscientists will participate in unique advisory council for the Institute

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Researchers setting up an experiment at the Allen Institute for Neural Dynamics

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Announcing the Allen Institute for Neural Dynamics, a new neuroscience division of the Allen Institute

Nov 4, 2021

New Institute will study how the brain’s circuitry and activity give rise to complex behavior, decision making and memory

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Several different types of neurons shown in position against a rendering of the mouse brain. Reconstructions of multiple cells in a circuit will help neuroscientists better piece together complete neural circuits. These neurons sit in the neocortex, the outermost shell of the mammalian brain.

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Now in stunning, whole-brain resolution: neurons

Oct 12, 2021

A new study traced the 3D shape of more than 1700 complete mouse neurons across the entire brain

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Stained neurons shown in slices of brain tissue from a human brain surgery patient who donated their tissue to research (two left images), a macaque monkey (second from right) and mouse brain (right). Allen Institute researchers are able to capture electrical information from these live human neurons, as well as their 3D shape and gene expression, through a technique known as Patch-seq. The human and macaque neurons are Betz cells, huge and specialized motor neurons that connect all the way to the spinal cord. These cells are a striking example of how similar types of neurons show specialization through evolution. The closest rodent relative to the primate Betz cell has very different features.

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New insights about evolution of human brain region that controls voluntary movement, including rare, large neurons vulnerable in ALS

Oct 6, 2021

Is our brain like that of a mouse or a monkey? New study aims to find our cellular similarities — and key differences

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A new study from the Allen Institute compares human brain cells’ molecular features to those of the marmoset monkey and mouse in a region of the brain that controls movement, the primary motor cortex. Using a technique known as single-cell transcriptomics, the researchers compared the suite of genes each individual brain cell switches on, across thousands of cells from each of the three species. Shown here, transcriptomic data clustered by type of brain cell, in the human (left), marmoset monkey (middle), and mouse brain (right)

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An ultra detailed map of the brain region that controls movement, from mice to monkeys to humans

Oct 6, 2021

Hundreds of neuroscientists built a ‘parts list’ of the motor cortex, laying groundwork to map the whole brain and better understand brain disease...

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A researcher at the Allen Institute for Brain Science prepares a piece of live human brain tissue for electrical recording.

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Living brain donors are helping us better understand our own neurons — including those potentially linked to Alzheimer’s disease

Oct 6, 2021

As part of an international effort to map cell types in the brain, scientists identified increased diversity of neurons in regions of the human brain...

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Image of human skull taken via MRI

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These rare human neurons generate electrical signals in two different cellular parts

Sep 16, 2021

With brain tissue samples donated by surgery patients come detailed descriptions of certain rare types of human cells — including new findings about...

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