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immunology

immune health and aging

interrogating immune cells and their responses across health and age
Aerial view of colorful circular forest patches with white water bodies in between

goals and approach

The Immune Health and Aging program at the Allen Institute's Immunology accelerator is focused on what defines a healthy immune system across age. Their interdisciplinary team of immunologists, technology developers, computational biologists and cloud computing specialists collaborate with researchers from around the world to enable large-scale studies on diverse human populations using cutting-edge, multi-omic tools that include single cell technologies, plasma proteomics, and integrative tissue biology techniques. They use these tools to deeply interrogate healthy immune responses and how these responses change with age, time and location. They strive to accelerate the understanding of immune heterogeneity and causes of age-related immune dysfunction and disease, and provide these foundational scientific resources to the global research community as part of a data exploration and integrative analysis platform.

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recent news

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news
How age affects vaccine responses and how to make them better
Age-related shifts in T cells weaken vaccine response in older adults, but new findings pave the way for next generation of vaccines.
multimedia
Key players in brain aging
New research identifies age-related damage on a cellular level.
news
Nature’s Palette: A tale of science and art
Two sisters, from seemingly different worlds, have joined forces in a unique collaboration to visualize the healthy immune system across age.

research details/

investigating the impact of age on T cells

The Immune Health and Aging Program, through its interdisciplinary nature, specializes in the application of innovative and novel technologies to address gaps in knowledge about human immune health. For example, using a tri-modal single cell technology called TEA-seq (measures transcription, open chromatin, and cell surface proteins) recently developed by our molecular biology team, we investigated the impact of age on T cells from healthy children and adults. This study revealed broad molecular re-programming of naïve T cells across age and led to the discovery of a novel population of T cells preferentially present in children.

View the summary article
Explore the open data

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Scatter plot comparing pediatric and adult immune cell populations by type with color coding

featured publications

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publication / 2025
Provide proactive reproducible analysis transparency with every publication
Royal Society Open Science
publication / 2025
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted
Nature
publication / 2025
CryoSCAPE: Scalable immune profiling using cryopreserved whole blood for multi-omic single cell and functional assays
Journal of Translational Medicine
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health and aging team

Kathleen Abadie
Bioinformatics Scientist
Claire Gustafson
Assistant Investigator
Mackenzie Kopp
Scientific Program Manager
Mansi Singh
Bioinformatics Analyst I
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Creating the deepest open reference for the healthy human immune system ever built.

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Engineering cells to record their own histories, transforming how we understand disease over time.

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