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Julia Han Noll

Scientist I

Allenite
/
Immunology
Health and Aging

biography

Julia completed her Ph.D. in Cellular and Molecular Biology at the University of Pennsylvania under the mentorship of Joseph Fraietta. Her doctoral research focused on how immune aging and inflammation influence the efficacy and safety of CAR T cell therapies. She investigated the role of T cell aging in chronic lymphocytic leukemia (CLL), identifying cellular and molecular features associated with impaired CAR T cell expansion and poor clinical outcomes. In parallel, she studied mechanisms driving immune-mediated toxicities following BCMA-directed CAR T cell therapy for multiple myeloma, uncovering inflammatory pathways associated with severe adverse events and potential therapeutic strategies to mitigate toxicity. Her work combined high-dimensional immune profiling, single-cell genomics and functional immunology to better understand the factors shaping cellular immunotherapy responses. During her Ph.D., she led studies published in Nature Medicine and other peer-reviewed journals, contributing new insights into both the efficacy and toxicity of CAR T cell therapies.

Prior to her doctoral training, Julia earned both her undergraduate and master's degrees in Molecular Biotechnology from Heidelberg University in Germany. She also gained international research experience at Tsinghua University in Beijing, China, and the National University of Singapore, providing early exposure to interdisciplinary research and international scientific collaborations.

In 2026, Julia joined the Allen Institute as a Scientist I in the Immune Health & Aging program led by Claire Gustafson. Her research examines the mechanisms that drive immune aging and how age-related changes in the immune system influence health and disease across the human lifespan. She aims to characterize normal immune variation as a foundation for identifying the causes of age-associated immune dysfunction and promoting healthy immune aging.

Outside of science, Julia enjoys arts and crafts, growing rare plants, swimming, cooking, and spending time with her two dogs.

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