Chemically active membranes in the generation of cell shape

This project challenges the assumption that the cell membrane is passive, changing shape only when acted upon by other forces. The researchers will use simulations, synthetic cells, and live archaeal cell communities to determine the chemical conditions that lead to tentacle-like protrusions used to explore the cell’s environment. This project will expand our knowledge of how cell membranes enable cells to interact dynamically with their environment in a broad ecological and evolutionary context. 

This project is part of the 2024 Membrane Biophysics cohort

Researchers in this cohort will focus on cellular membranes that separate cell contents from the surrounding environment, allow cells to change shape, exchange materials, and respond to their environment. Despite having been implicated in numerous human diseases, little is known about the principles governing cell membrane biology and biophysics. This cohort will expand the frontiers of our understanding of fundamental aspects of cell membrane form, function, and dynamics using innovative technologies and analytical frameworks, with important implications for basic science and human health.