Chemically active membranes in the generation of cell shape

In vivo, membranes exist in non-equilibrium states and host numerous chemical reactions. Here, building on preliminary data, we hypothesize that chemical reactions hosted on the membrane surface can drive drastic membrane reshaping when such a membrane is embedded in an environment rich in reactants. We further hypothesize that this, previously unidentified, mechanism for membrane reshaping is an important driving force behind cell shape changes in ecological communities, where cellular membranes grow long directional tentacles to consume each other’s chemicals, even without the presence of cytoskeleton. To test this hypothesis, we will combine theoretical, in vitro, and in vivo approaches. Coarse-grained computer simulations will be used to define the principles by which chemical activity can reshape membranes, making testable predictions for experiments. 

• The generation and control of chemically-driven protrusions. 

• Functional analysis: What are chemically-driven membrane protrusions useful for? 

This project is part of the 2024 Membrane Biophysics cohort

Researchers in this cohort will focus on cellular membranes that separate cell contents from the surrounding environment, allow cells to change shape, exchange materials, and respond to their environment. Despite having been implicated in numerous human diseases, little is known about the principles governing cell membrane biology and biophysics. This cohort will expand the frontiers of our understanding of fundamental aspects of cell membrane form, function, and dynamics using innovative technologies and analytical frameworks, with important implications for basic science and human health.