Solving the mysteries of bioscience
Foundational Science Fuels Breakthroughs
Inspiring Next-Generation Scientists
Exploring the brain’s activity, at the level of individual neurons and the whole brain, to reveal how we interpret our environments to make decisions.
Goals and Approach
How do our brains understand the world around us to guide fundamental human behaviors? To answer these questions, scientists at the Allen Institute for Neural Dynamics are analyzing and tracing the path of neural signals in neural circuits cascading and interacting across the whole brain and body. Their approach is focused on how the brain works rather than what it is made of at a cellular or molecular level. Teams of researchers working collaboratively develop next-generation neuro-technologies that capture massive amounts of data that are shared with the wider scientific community. The goal is to catalyze scientific discovery that will lead to treatments and therapies for brain disorders.
We aim to discover how neurons’ activity – and changes in that activity – allow the brain to perform complex but fundamental computations and drive flexible behaviors.
Our experiments and open resources will shed light on behavior, memory, how we handle uncertainty and risk, how we and other animals chase rewards, and how some or all of these complicated cognitive functions go awry in neuropsychiatric disorders such as depression, ADHD, or addiction.
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09.24.2024
08.26.2024
08.02.2024
Monitoring and manipulating spikes with high specificity to open up new avenues for understanding the neural underpinnings of behavior.
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Aiming to generate comprehensive descriptions of neuronal types and examine connectivity at various scales in defined cell types.
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Measuring neural circuit functions using light-sensitive molecules.
Using multiple approaches to investigate how the brain adaptively controls behavior and internal organ function.
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A platform for high-throughput and reproducible neurophysiology, openly available to run experiments for external scientists.
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Creating a best-in-class open, reproducible, and scalable platform for scientific data storage, analysis, and sharing.
Investigating how the nervous system learns and makes decisions in dynamic environments.
Neuron
Sep 04, 2024
Corbett Bennett, Ben Ouellette, Tamina K. Ramirez, Alex Cahoon, Hannah Cabasco, Yoni Browning, Anna Lakunina, Galen F. Lynch, Ethan G. McBride, Hannah Belski, Ryan Gillis, Conor Grasso, Robert Howard, Tye Johnson, Henry Loeffler, Heston Smith, David Sullivan, Allison Williford, Shiella Caldejon, Severine Durand, Samuel Gale, Alan Guthrie, Vivian Ha, Warren Han, Ben Hardcastle, Chris Mochizuki, Arjun Sridhar, Lucas Suarez, Jackie Swapp, Joshua Wilkes, Joshua H. Siegle, Colin Farrell, Peter A. Groblewski, Shawn R. Olsen
Jun 05, 2024
Alex Piet, Nick Ponvert, Douglas Ollerenshaw, Marina Garrett, Peter A. Groblewski, Shawn Olsen, Christof Koch, Anton Arkhipov
Journal of Neural Engineering
Sep 18, 2023
Alessio P. Buccino, Olivier Winter, David Bryant, David Feng, Karel Svoboda, Joshua H. Siegle
08.24.2025 - 09.07.2025
Understanding life. Advancing health.
The Allen Institute is an independent nonprofit bioscience research institute aimed at unlocking the mysteries of biology.
We are leaders in large-scale research that transforms our understanding of health and disease and shapes how science is conducted worldwide.