Team

Staff Profiles

R. Clay Reid, M.D., Ph.D.

Senior Investigator

R. Clay Reid joined the Allen Institute in 2012 to study how information is encoded and processed in neural networks of the visual system, using behavior, anatomy and physiology. Prior to joining the Allen Institute, Reid served as Professor of Neurobiology at Harvard Medical School, where he had been on the faculty for fifteen years. Reid is a recognized authority on how the brain processes and makes sense of visual information, and has approached these topics from a variety of methods including electrophysiology, imaging, and quantitative analysis. Most recently he has used a combination of imaging and anatomical approaches to investigate how the structure of neural connections relates to functional brain circuitry. He has helped to pioneer new methods for recording increasingly large groups of neurons simultaneously in order to study information processing in neuronal populations. A recipient of the Klingenstein Fellowship in 1993 and the Society for Neuroscience Young Investigator Award in 2001, Reid has long been regarded as a pioneering leader in the field. Reid holds B.S. degrees in Mathematics and in Physics and Philosophy from Yale University, a Ph.D. from the Rockefeller University, and an M.D. from Cornell University Medical College.

Selected Publications View Publications

Chromatic micromaps in primary visual cortex

Nature Communications
April 19, 2021

Chatterjee S, Ohki K, Reid RC

Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice

eLife
March 8, 2021

Huang L, Ledochowitsch P, Knoblich U, Lecoq J, Murphy GJ, Reid RC, de Vries SEJ, Koch C, Zeng H, Buice MA, Waters J, Li L

Survey of spiking in the mouse visual system reveals functional hierarchy

Nature
January 20, 2021

Siegle JH, Jia X, Durand S, Gale S, Bennett C, Graddis N, Heller G, Ramirez TK, Choi H, Luviano JA, Groblewski PA, Ahmed R, Arkhipov A, Bernard A, Billeh YN, Brown D, Buice MA, Cain N, Caldejon S, Casal L, Cho A, Chvilicek M, Cox TC, Dai K, Denman DJ, de Vries S., Dietzman R, Esposito L, Farrell C, Feng D, Galbraith J, Garrett M, Gelfand EC, Hancock N, Harris JA, Howard R, Hu B, Hytnen R, Iyer R, Jessett E, Johnson K, Kato I, Kiggins J, Lambert S, Lecoq J, Ledochowitsch P, Lee JH, Leon A, Li Y, Liang E, Long F, Mace K, Melchior J, Millman D, Mollenkopf T, Nayan C, Ng L, Ngo D, Nguyen T, Nicovich PR, North K, Ocker GK, Ollerenshaw D, Oliver M, Pachitariu M, Perkins J, Reding M, Reid D, Robertson M, Ronellenfitch K, Seid S, Slaughterbeck C, Stoecklin M, Sullivan D, Sutton B, Swapp J, Thompson C, Turner K, Wakeman W, Whitesell JD, Williams D, Williford A, Young R, Zeng H, Naylor S, Phillips JW, Reid RC, Mihalas S, Olsen SR, Koch C

The Mind of a Mouse

Cell
September 17, 2020

Abbott LF, Bock DD, Callaway EM, Denk W, Dulac C, Fairhall AL, Fiete I, Harris KM, Helmstaedter M, Jain V, Kasthuri N, LeCun Y, Lichtman JW, Littlewood PB, Luo L, Maunsell JHR, Reid RC, Rosen BR, Rubin GM, Sejnowski TJ, Seung HS, Svoboda K, Tank DW, Tsao D, Van Essen DC

Capillary- and Stokes-based trapping of serial sections for scalable 3D-EM connectomics

eNeuro
February 24, 2020

Lee TJ, Yip MC, Kumar A, Lewallen CF, Bumbarger DJ, Reid RC, Forest CR

VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli

eLife
October 27, 2020

Millman DJ, Ocker GK, Caldejon S, Kato I, Larkin JD, Lee EK, Luviano J, Nayan C, Nguyen TV, North K, Seid S, White C, Lecoq J, Reid C, Buice MA, de Vries SE

A petascale automated imaging pipeline for mapping neuronal circuits with high-throughput transmission electron microscopy

Nature Communications
October 2, 2020

Yin W, Brittain D, Borseth J, Scott ME, Williams D, Perkins J, Own CS, Murfitt M, Torres RM, Kapner D, Mahalingam G, Bleckert A, Castelli D, Reid D, Lee WA, Graham BJ, Takeno M, Bumbarger DJ, Farrell C, Reid RC, da Costa NM

A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex

Nature Neuroscience
December 16, 2019

de Vries S, Lecoq J, Buice MA, Groblewski PA, Ocker GK, Oliver M, Feng F, Cain N, Ledochowitsch P, Millman D, Roll K, Garrett M, Keenan T, Kuan L, Mihalas S, Olsen S, Thompson C, Wakeman W, Waters J, Williams D, Barber C, Berbesque N, Blanchard B, Bowles N, Caldejon S, Casal L, Cho A, Cross S, Dang C, Dolbeare T, Edwards M, Galbraith J, Gaudreault N, Griffin F, Hargrave P, Howard R, Huang L, Jewell S, Keller N, Knoblich U, Larkin J, Larsen R, Lau C, Lee E, Lee F, Leon A, Li L, Long F, Luviano J, Mace K, Nguyen T, Perkins J, Robertson M, Seid S, Shea-Brown E, Shi J, Sjoquist N, Slaughterbeck C, Sullivan D, Valenza R, White C, Williford A, Witten D, Zhuang J, Zeng H, Farrell C, Ng L, Bernard A, Phillips JW, R Reid C, Koch C

Transport and trapping of nanosheets via hydrodynamic forces and curvature-induced capillary quadrupolar interactions

Elsevier
July 18, 2018

Lee TJ, Lewallen CF, Bumbarger DJ, Yunker PJ, Reid RC, Forest CR

Visual physiology of the Layer 4 cortical circuit in silico

PLoS Computational Biology
November 12, 2018

Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-LLavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C

Large-scale neuroanatomy using LASSO: Loop-based Automated Serial Sectioning Operation

PLOS One
October 23, 2018

Lee TJ, Kumar A, Balwani AH, Brittain D, Kinn S, Tovey CA, Dyer EL, da Costa NM, Reid RC, Forest CR, Bumbarger DJ

Cortico-cortical projections in mouse visual cortex are functionally target specific

Nature Neuroscience
January 13, 2013

Glickfeld LL, Andermann ML, Bonin V, Reid CR

Observatories of the mind

Nature
March 21, 2012

Koch C & Reid RC