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Jérôme Lecoq

Associate Investigator

teams /
Allenite

Jérôme Lecoq joined the Allen Institute in 2015 to lead efforts in mapping cortical computation using in vivo two-photon microscopy in behaving animals. He brings 10 years of experience in in vivo microscopy working with rodents. Prior to joining the Allen Institute, Lecoq was a postdoctoral scholar in Mark Schnitzer’s group at Stanford University, where he developed novel imaging methodologies to monitor large neuronal populations in the visual cortex of behaving mice. Lecoq received a Ph.D. in Neuroscience from the Pierre and Marie Curie University in Paris and an M.S. in Physics from ESPCI ParisTech, a French multidisciplinary engineering school.

research focus

To truly comprehend the complexities of the cortex, we must delve into its computational principles and build models that capture the essence of its workings. However, to fully test these models, we need datasets that accurately measure the neuronal representations that we seek to understand at the scale of the entire brain.As a researcher, I am passionate about building innovative platforms that revolutionize the way we understand the brain. One such platform that I have helped build and continue to develop is OpenScope, which draws inspiration from the field of astronomy to create the first brain observatory.OpenScope aims to democratize neuroscience by providing an open platform where researchers can study the brain's complex activities. Through this platform, researchers can observe how the brain responds to stimuli in real-time and create large-scale datasets that enable a deeper understanding of the brain's computational principles. The high-throughput imaging platform that I continue to improve is a crucial component of OpenScope, allowing for real-time recordings of neuronal activity and enabling a more comprehensive understanding of the brain's workings.

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featured stories

news
Scientists shoot lasers into brain cells to uncover how illusions work
Supported by the Allen Institute's OpenScope program, the findings could help us better understand neuropsychiatric disorders like schizophrenia and...
news
World’s first crowd-sourced neuroscience study aims to understand how our brains predict the future
Using the Allen Institute’s OpenScope platform, experiments will probe brain functions related to "predictive processing"
video
The World's Observatory of the Mind | OpenScope
Great questions can come from anywhere. OpenScope is an open platform for high-throughput and reproducible neurophysiology.

featured media

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featured publications

publication / 2025
Integrating multimodal data to understand cortical circuit architecture and function
Nature Neuroscience
publication / 2025
Unexpected Events Trigger Task-Independent Signaling in VIP and Excitatory Neurons of Mouse Visual Cortex
iScience
publication / 2024
Taste for discovery: a conversation with neuroscientist Serge Charpak
Neurophotonics
publication / 2023
Responses to pattern-violating visual stimuli evolve differently over days in somata and distal apical dendrites
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience
preprint / 2023
Recurrent pattern completion drives the neocortical representation of sensory inference
preprint / 2023
Stimulus novelty uncovers coding diversity in visual cortical circuits
publication / 2022
Emergent reliability in sensory cortical coding and inter-area communication
Nature
publication / 2022
Measuring Stimulus-Evoked Neurophysiological Differentiation in Distinct Populations of Neurons in Mouse Visual Cortex
eNeuro
publication / 2022
A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
eNeuro
publication / 2021
Removing independent noise in systems neuroscience data using DeepInterpolation
Nature Methods
publication / 2021
Reconciling functional differences in populations of neurons recorded with two-photon imaging and electrophysiology
eLife
publication / 2021
Survey of spiking in the mouse visual system reveals functional hierarchy
Nature
publication / 2021
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice
eLife
publication / 2020
VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli
eLife
publication / 2020
A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex
Nature Neuroscience
publication / 2019
Wide. Fast. Deep: Recent Advances in Multiphoton Microscopy of In Vivo Neuronal Activity
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience
publication / 2019
Hierarchical organization of cortical and thalamic connectivity
Nature
publication / 2019
Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse
PloS One
publication / 2018
Visual physiology of the layer 4 cortical circuit in silico
PLoS computational biology
publication / 2018
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
Cell
publication / 2017
Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
eNeuro
publication / 2016
Long-Term Optical Access to an Estimated One Million Neurons in the Live Mouse Cortex
Cell Reports
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