Christof Koch, Ph.D.
Chief Scientist & President
Christof Koch is the Chief Scientist and President of the Allen Institute for Brain Science.
Christof received his baccalaureate from the Lycée Descartes in Rabat, Morocco, his B.S. and M.S. in physics from the University of Tübingen in Germany and his Ph.D. from the Max-Planck Institute for biological Cybernetics in 1982. Subsequently, he spent four years as a postdoctoral fellow in the Artificial Intelligence Laboratory and the Brain and Cognitive Sciences Department at the Massachusetts Institute of Technology. From 1987 until 2013, Koch was a professor at the California Institute of Technology (Caltech) in Pasadena, from his initial appointment as Assistant Professor, Division of Biology and Division of Engineering and Applied Sciences in 1986, to his final position as Lois and Victor Troendle Professor of Cognitive & Behavioral Biology. See here for Christof's academic pedigree and his students. Christof joined the Allen Institute for Brain Science as Chief Scientific Officer in 2011 and became President in 2015.
Christof’s passion are neurons – the atoms of perception, memory, behavior and consciousness – their diverse shapes, electrical behaviors, and their computational function within the mammalian brain, in particular in neocortex. The Allen Institute for Brain Science is engaged in a major effort to identify all the different types of neurons in the brains of mice and humans – the cell census effort. See the papers below.
Christof discovered that in vivo cortical neurons do not integrate over large number of small inputs given their spiking variability, how neurons can multiply, the relationship between intra- and extra-cellular potential, and how this gives rise to the local field potential and the large-scale current sinks and sources and how weak extracellular fields can entrain spiking activity via ephaptic effects. He postulated the attentional saliency map hypothesis for biological and computer vision according to which one or more topographic organized spatial maps summarize bottom-up salient information in the visual system, he co-discovered, with Itzhak Fried, an high-level, invariant and abstract single neuron representation of familiar individuals and objects in the human medial temporal lobe (the so-called “Jennifer Aniston” or concept neurons) and developed the ‘continuous flashed suppression’ masking technique. In collaboration with Francis Crick, he initiated the modern search for the neuronal correlates of consciousness, a systematic experimental program to identify the minimal bio-physical mechanisms jointly sufficient for any one specific conscious percept. In collaboration with Giulio Tononi, he co-developed the Integrated Information Theory of consciousness.
Christof writings and interests integrate theoretical, computational and experimental neuroscience with philosophy and contemporary trends, in particular artificial intelligence. His latest book, The Feeling of Life Itself – Why Consciousness is Everywhere But Can’t be Computed, will be published by MIT Press in fall of 2019.
His previous book, Consciousness: Confessions of a Romantic Reductionist, blends science and memoir to explore topics in discovering the roots of consciousness. Stemming in part from a long-standing collaboration with the late Nobel Laureate Francis Crick, Christof authored the book The Quest for Consciousness: A Neurobiological Approach. Koch also authored the technical books Biophysics of Computation: Information Processing in Single Neurons and Methods in Neuronal Modeling: From Ions to Networks, and served as editor for several books on neural modeling and information processing.
Visit Christof's Wikipedia page.
Selected Publications View on PUBMED
Classification of electrophysiological and morphological types in mouse visual cortex
Nature Neuroscience
June 17, 2019
Gouwens NW, Sorensen SA, Berg J, Lee C, Jarsky T, Ting J, Sunkin S, Feng D, Anastassiou C, Barkan E, Bickley K, Blesie N, Braun T, Brouner K, Budzillo A, Caldejon S, Casper T, Castelli D, Chong P, Crichton K, Cuhaciyan C, Daigle T, Dalley R, Dee N, Desta T, Dingman S, Doperalski A, Dotson N, Egdorf T, Fisher M, de Frates RA, Garren E, Garwood M, Gary A, Gaudreault N, Godfrey K, Gorham M, Gu H, Habel C, Hadley K, Harrington J, Harris J, Henry A, Hill D, Josephsen S, Kebede S, Kim L, Kroll M, Lee B, Lemon T, Liu X, Long B, Mann R, McGraw M, Mihalas S, Mukora A, Murphy GJ, Ng L, Ngo K, Nguyen TN, Nicovich PR, Oldre A, Park D, Parry S, Perkins J, Potekhina L, Reid D, Robertson M, Sandman D, Schroedter M, Slaughterbeck C, Soler-Llavina C, Sulc J, Szafer A, Tasic B, Taskin N, Teeter C, Thatra N, Tung H, Wakeman W, Williams G, Young R, Zhou Z, Farrell C, Peng H, Hawrylycz MJ, Lein E, Ng L, Arkhipov A, Bernard A, Phillips J, Zeng H, Koch C
Journal of Neurophysiology
March 6, 2019
Jia X, Siegle JH, Bennett C, Gale SD, Denman DJ, Koch C, Olsen SR
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
eLife
September 26, 2018
Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee, JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T
BioNet: A Python interface to NEURON for modeling large-scale networks
PLOS | ONE
August 2, 2018
Gratiy SL, Billeh YN, Dai K, Mitelut C, Feng D, Gouwens NW, Cain N, Koch C, Anastassiou CA, Arkhipov A
bioRxiv
June 29, 2018
de Vries S, Lecoq J, Buice MA, Groblewski PA, Ocker GK, Oliver M, Feng F, Cain N, Ledochowitsch P, Millman D, Roll K, Garrett M, Keenan T, Kuan L, Mihalas S, Olsen S, Thompson C, Wakeman W, Waters J, Williams D, Barber C, Berbesque N, Blanchard B, Bowles N, Caldejon S, Casal L, Cho A, Cross S, Dang C, Dolbeare T, Edwards M, Galbraith J, Gaudreault N, Griffin F, Hargrave P, Howard R, Huang L, Jewell S, Keller N, Knoblich U, Larkin J, Larsen R, Lau C, Lee E, Lee F, Leon A, Li L, Long F, Luviano J, Mace K, Nguyen T, Perkins J, Robertson M, Seid S, Shea-Brown E, Shi J, Sjoquist N, Slaughterbeck C, Sullivan D, Valenza R, White C, Williford A, Witten D, Zhuang J, Zeng H, Farrell C, Ng L, Bernard A, Phillips JW, R Reid C, Koch C
Human single neuron activity precedes emergence of conscious perception
Nature Communications
May 25, 2018
Gelbard-Sagiv H, Mudrik L, Hill M, Koch C, Fried I
The organization of intracortical connections by layer and cell class in the mouse brain
bioRxiv
April 18, 2018
Harris JA, Mihalas S, Hirokawa KE, Whitesell JD, Knox J, Bernard A, Bohn P, Caldejon S, Casal L, Cho A, Feng D, Gaudreault N, Gerfen C, Graddis N, Groblewski PA, Henry A, Ho A, Howard R, Kuan L, Lecoq J, Luviano J, McConoughey S, Mortrud M, Naeemi M, Ng L, Oh SW, Ouellette B, Sorensen SA, Wakeman W, Wang Q, Williford A, Phillips J, Jones A, Koch C, Zeng H
Systematic generation of biophysically detailed models for diverse cortical neuron types
Nature Communications
February 19, 2018
Gouwens NW, Berg J, Feng D, Sorensen SA, Zeng H, Hawrylycz MJ, Koch C, and Arkhipov A
Generalized leaky integrate-and-fire models classify multiple neuron types
Nature Communications
February 19, 2018
Teeter C, Iyer R, Menon V, Gouwens N, Feng D, Berg J, Szafer A, Cain N, Zeng H, Hawrylycz M, Koch C, Mihalas S
Visual physiology of the Layer 4 cortical circuit in silico
PLoS Computational Biology
November 12, 2018
Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-LLavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C
Neuron
November 1, 2018
Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, Bakken TE, Hodge RD, Chong P, de Frates R, Dai K, Maltzer Z, Nicovich PR, Keene CD, Silbergeld DL, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Koch C, Anastassiou CA, Lein ES, Ting JT
Shared and distinct transcriptomic cell types across neocortical areas
Nature
October 31, 2018
Tasic B, Yao Z, Graybuck LT, Smith KA, Nguyen TN, Bertagnolli D, Goldy J, Garren E, Economo MN, Viswanathan S, Penn O, Bakken T, Menon V, Miller J, Fong O, Hirokawa KE, Lathia K, Rimorin C, Tieu M, Larsen R, Casper T, Barkan E, Kroll M, Parry S, Shapovalova NV, Hirschstein D, Pendergraft J, Sullivan HA, Kim TK, Szafer A, Dee N, Groblewski P, Wickersham I, Cetin A, Harris JA, Levi BP, Sunkin SM, Madisen L, Daigle TL, Looger L, Bernard A, Phillips J, Lein E, Hawrylycz M, Svoboda K, Jones AR, Koch C, Zeng H
From Maxwell's equations to the theory of current-source density analysis
European Journal of Neuroscience
February 8, 2017
Gratiy SL, Halnes G, Denman D, Hawrylycz MJ, Koch C, Einevoll GT, Anastassiou CA
Neural correlates of consciousness: progress and problems
Nature Reviews Neuroscience
April 20, 2016
Koch C, Massimini M, Boly M, Tononi G
Journal of Vision
January 1, 2016
Gelbard-Sagiv H, Faivre N, Mudrik L, Koch C
Local Field Potentials Encode Place Cell Ensemble Activation during Hippocampal Sharp Wave Ripples
Neuron
August 5, 2015
Taxidis J, Anastassiou CA, Diba K, Koch C
Automated High-Throughput Characterization of Single Neurons by Means of Simplified Spiking Models
PLoS Computational Biology
June 17, 2015
Pozzorini C, Skander M, Hagens O, Naud R, Koch C, Gerstner W
Consciousness: here, there and everywhere?
Philosophical Transactions of the Royal Society of London
May 19, 2015
Tononi G, Koch C
Emergence of slow-switching assemblies in structured neuronal networks
arXiv
February 23, 2015
Schaub MT, Billeh YN, Anastassiou CA, Koch C, Barahona M
Neuron
July 24, 2013
Reimann MW, Anastassiou CA, Perin R, Hill SL, Markram H, Koch C