Team

Staff Profiles

Adam Glaser, Ph.D.

Scientist, Sr.

Adam Glaser joined the Allen Institute for Neural Dynamics in 2021. He works in the multi-scale molecular neuroanatomy group, focusing on the development of hardware and software tools for large-scale imaging projects. Prior to joining the institute, he worked as a postdoctoral research associate in the Department of Mechanical Engineering at the University of Washington, where he is now an Affiliate Assistant Professor. There he worked in Jonathan Liu’s laboratory, leading the development of open-top light-sheet microscopy systems for three-dimensional clinical pathology. He earned his Ph.D. in Engineering Sciences from Dartmouth College in 2015, and B.S. in Mechanical Engineering from Tufts University in 2010.

Research

Research Interests

New breakthroughs in microscopy and tissue chemistry are revolutionizing our ability to study the structural and molecular contents of cells, tissues, and organs. Visualizing these components with spatial context and in three dimensions yields a more holistic view of complex biological systems. I am interested in developing the hardware and software tools which will enable the acquisition, visualization, and analysis of these datasets at scale.

Expertise

  • Light-sheet microscopy
  • Large-scale imaging
  • Open-source tools

Research Programs

  • Multi-scale molecular neuroanatomy

Selected Publications View Publications

A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues

Nature Methods
May 11, 2022

Glaser AK, Bishop KW, Barner LA, Susaki EA, Kubota SI, Gao G, Serafin RB, Balaram P, Turschak E, Nicovich PR, Lai H, Lucas LAG, Yi Y, Nichols EK, Huang H, Reder NP, Wilson JJ, Sivakumar R, Shamskhou E, Stoltzfus CR, Wei X, Hempton AK, Pende M, Murawala P, Dodt HU, Imaizumi T, Shendure J, Beliveau BJ, Gerner MY, Xin L, Zhao H, True LD, Reid RC, Chandrashekar J, Ueda HR, Svoboda K, Liu JTC

A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues

Nature Methods
May 11, 2022

Glaser A, Bishop KW, Barner LA, Susaki EA, Kubota SI, Gao G, Serafin RB, Balaram P, Turschak E, Nicovich PR, Lai H, Lucas LAG, Yi Y, Nichols EK, Huang H, Reder NP, Wilson JJ, Sivakumar R, Shamskhou E, Stoltzfus CR, Wei X, Hempton AK, Pende M, Murawala P, Dodt HU, Imaizumi T, Shendure J, Beliveau BJ, Gerner MY, Xin L, Zhao H, True LD, Reid RC, J C, Ueda HR, Svoboda K, Liu JTC

Fluorescent labeling of abundant reactive entities (FLARE) for cleared-tissue and super-resolution microscopy

Nature Protocols
February 2, 2022

Lee MY, Mao C, Glaser AK, Woodworth MA, Halpern AR, Ali A, Liu JTC, Vaughan JC

Harnessing the potential of nondestructive 3D pathology: A technological and translational roadmap

Nature Biomedical Engineering
February 15, 2021

Liu, J. T., Glaser, A. K., Bera K., True, L. T., Reder, N. P., Eliceir, K. W., Madabhushi, A.

Feature-Rich Covalent Stains for Super-Resolution and Cleared-Tissue Fluorescence Microscopy

Science Advances
May 27, 2020

Mao C., Lee M., Jhan J., Halpern A. R., Chozinski T. J., Shin L., Glaser, A. K., Liu, J. T., Vaughan, J. C.

Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

Nature Communications
July 4, 2019

Glaser, A. K., Reder, N. P., Chen, Y., Yin, C., Wei, L., Kang, S., Barner, L. A., Xie, W., McCarty, E. F., Mao, C., Halpern, A. R., Stoltzfus, C. R., Daniels, J. S., Gerner, M. Y., Nicovich, P. R., Vaughan, J. C., True, L. D. & Liu, J. T.

Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens

Nature Biomedical Engineering
June 26, 2017

Glaser, A. K., Reder, N. P., Chen, Y., McCarty, E. F., Yin, C., Wei, L., Wang, Y., True, L. D., Liu, J. T.

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