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Adam Glaser

Scientist, Sr.

teams /
Allenite

Adam Glaser joined the Allen Institute for Neural Dynamics in 2021. He works in the multi-scale molecular neuroanatomy group, focusing on the development of hardware and software tools for large-scale imaging projects. Prior to joining the institute, he worked as a postdoctoral research associate in the Department of Mechanical Engineering at the University of Washington, where he is now an Affiliate Assistant Professor. There he worked in Jonathan Liu’s laboratory, leading the development of open-top light-sheet microscopy systems for three-dimensional clinical pathology. He earned his Ph.D. in Engineering Sciences from Dartmouth College in 2015, and B.S. in Mechanical Engineering from Tufts University in 2010.

research focus

New breakthroughs in microscopy and tissue chemistry are revolutionizing our ability to study the structural and molecular contents of cells, tissues, and organs. Visualizing these components with spatial context and in three dimensions yields a more holistic view of complex biological systems. I am interested in developing the hardware and software tools which will enable the acquisition, visualization, and analysis of these datasets at scale.

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video
Scientific Overview | ExA-SPIM
A high-level explanation of the protocols necessary to implement the Expansion Selective Plane Illumination Microscopy (ExA–SPIM) pipeline
video
A new, custom-built microscope is capturing stunning views of the brain
‘ExA-SPIM’ microscope borrows from electronics industry to image incredible detail in an entire mouse brain
video
Look in the labs | Neural Dynamics
How do different brain regions connect and communicate? Researchers at the Allen Institute for Neural Dynamics are 3D imaging whole mouse brains in...

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publication / 2025
Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
eLife
publication / 2024
Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues
eLife
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