Solving the mysteries of bioscience
Foundational Science Fuels Breakthroughs
Inspiring Next-Generation Scientists
Explore how scientists use their knowledge of transcription, immunolabeling, and bioethics to understand Alzheimer’s disease pathology.
About this resource:
This collection of four lesson plans walks students through how scientists work with donated brain tissue to study how the healthy human brain differs from a brain with Alzheimer’s neuropathology. Throughout these lessons, students are asked to consider both the social and biological contexts of Alzheimer’s disease while looking at data from single brain cells about which genes they are or are not expressing relative to their cellular neighbors in the brain. Students are also guided through an interactive image dataset of immunolabeled brain tissue, allowing students to compare the presence and/or absence of biological hallmarks thought to be associated with Alzheimer’s disease pathology.
Audience: introductory to intermediate college-level cell science and/or neuroscience students, or advanced high school students
Mode of instruction: suitable for remote, hybrid, or in-person instruction
Note: Each lesson features an instructor guide and a student worksheet.
Lesson 1: Brain Donation and Bioethics
Lesson 2: The Importance of Basic Research in Brain Science
Lesson 3: Societal and Biological Perspectives on Alzheimer’s Disease
Lesson 4: Analyzing Transcriptomic Data to Explore Alzheimer’s Disease Pathology
Data used in this unit: