About this resource:

This collection of four lesson plans walks students through how scientists work with donated brain tissue to study how the healthy human brain differs from a brain with Alzheimer’s neuropathology. Throughout these lessons, students are asked to consider both the social and biological contexts of Alzheimer’s disease while looking at data from single brain cells about which genes they are or are not expressing relative to their cellular neighbors in the brain. Students are also guided through an interactive image dataset of immunolabeled brain tissue, allowing students to compare the presence and/or absence of biological hallmarks thought to be associated with Alzheimer’s disease pathology.

Audience: introductory to intermediate college-level cell science and/or neuroscience students, or advanced high school students

Mode of instruction: suitable for remote, hybrid, or in-person instruction

Lesson Materials:

Note: Each lesson features an instructor guide and a student worksheet.

Lesson 1: Brain Donation and Bioethics

• • In this lesson, students are asked to explore the field of bioethics in order to understand the importance of consent within biomedical research.

Lesson 2: The Importance of Basic Research in Brain Science

• • In this lesson, students are challenged to use their knowledge of transcription to explore gene expression between different types of cells within the healthy human brain.

Lesson 3: Societal and Biological Perspectives on Alzheimer’s Disease

• • In this lesson, students are guided through an exploration of real immunolabeled neuropathology images from donors with and without dementia in order to look for the presence and/or absence of neurofibrillary tangles.

Lesson 4: Analyzing Transcriptomic Data to Explore Alzheimer’s Disease Pathology

• • In this lesson, students analyze transcriptomic data to search for possible biological markers of Alzheimer’s disease.

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