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Dr. Müschen is exploring a protein called LGR5 found in multiple B-cell malignancies such as B-cell acute lymphoblastic leukemia, mantle cell lymphoma and diffuse large B-cell lymphoma, as a potential diagnostic marker and therapeutic target. He is planning to test small molecule inhibitors and different immunotherapies in preclinical models.
Over the past 10 years, the Markus Müschen laboratory has developed a multidisciplinary research program to study oncogenic signaling and clonal evolution in B cell malignancies, including acute lymphoblastic leukemia (ALL), the most frequent type of cancer in children and young adults.