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Dr. Gary Firestein is director of the Clinical and Translational Research Institute, dean and associate vice chancellor of clinical and translational research and distinguished professor of medicine at the University of California San Diego. He joined the faculty as an assistant professor of medicine in 1988. Four years later, he was recruited by Gensia, Inc. to be director of immunology. At Gensia, he supervised drug discovery efforts, focusing on the potential role of purines in inflammation. In 1996, he returned to UC San Diego Health where he served as chief of the Division of Rheumatology, Allergy and Immunology from 1998 to 2010. Dr. Firestein’s research focuses on the pathogenesis and treatment of rheumatoid arthritis. He was among the first to map the cytokine profile of rheumatoid arthritis and demonstrate the dominance of macrophage and fibroblast products. These studies played a pivotal role in the development of highly effective anti-TNF and other anti-cytokine therapies for rheumatoid arthritis.