Bert Bertagnolli

Nature

Comparative cellular analysis of motor cortex in human, marmoset and mouse

Oct 01, 2021

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals1. Here, using high-throughput...

Nature

A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex

Oct 01, 2021

Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased samples of the diverse cell types in the brain1-3. With...

Nature

Human neocortical expansion involves glutamatergic neuron diversification

Oct 01, 2021

The neocortex is disproportionately expanded in human compared with mouse1,2, both in its total volume relative to subcortical structures and in the...

eLife

Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans

Sep 02, 2021

Abundant evidence supports the presence of at least three distinct types of thalamocortical (TC) neurons in the primate dorsal lateral geniculate...

Cell

A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

Jun 10, 2021

The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning. We profiled...

Cell Reports

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

Mar 30, 2021

Viral genetic tools that target specific brain cell types could transform basic neuroscience and targeted gene therapy. Here, we use comparative open...

Cell

Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells

Nov 12, 2020

Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the...

Nature

Conserved cell types with divergent features in human versus mouse cortex

Sep 01, 2019

Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease....

Nature

Shared and distinct transcriptomic cell types across neocortical areas

Nov 01, 2018

The neocortex contains a multitude of cell types that are segregated into layers and functionally distinct areas. To investigate the diversity of cell...

Science (New York, N.Y.)

An anatomic transcriptional atlas of human glioblastoma

May 11, 2018

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their...

PloS One

Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

Jan 01, 2018

Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA-sequencing...

eLife

Neuropathological and transcriptomic characteristics of the aged brain

Nov 09, 2017

As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific...

Nature

A comprehensive transcriptional map of primate brain development

Jul 21, 2016

The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We...

Nature Neuroscience

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

Feb 01, 2016

Nervous systems are composed of various cell types, but the extent of cell type diversity is poorly understood. We constructed a cellular taxonomy of...

Human Molecular Genetics

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome

Aug 01, 2015

Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions...

Nature

Transcriptional landscape of the prenatal human brain

Apr 10, 2014

The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically...

Nature

An anatomically comprehensive atlas of the adult human brain transcriptome

Sep 20, 2012

Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources to complement genomic sequence data and to correlate...

Proceedings of the National Academy of Sciences of the United States of America

Divergent and nonuniform gene expression patterns in mouse brain

Nov 02, 2010

Considerable progress has been made in understanding variations in gene sequence and expression level associated with phenotype, yet how genetic...

Bert Bertagnolli

Publications