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Carl Ware Headshot

Carl F. Ware, Ph.D.

Sanford Burnham Prebys Medical Discovery Institute

Bio:

Carl F. Ware, Ph.D. is Professor and Director of the Infectious and Inflammatory Diseases Center and Member of the NCI-designated Cancer Center at Sanford Burnham Prebys Medical Discovery Institute. As a leading internationally recognized immunologist his discoveries and advances in the study of the immune system are leading to new therapeutics for autoimmune diseases and cancer. Dr. Ware received his Ph.D. in Molecular Biology and Biochemistry from the University of California, Irvine, and was awarded a prestigious National Research Service Award from the NIH to support his postdoctoral training in biochemistry and immunology with Tim Springer and Jack Strominger at the Dana-Farber Cancer Institute, Harvard Medical School. Dr. Ware established his research laboratory in Immunology and Virology at the University of California, Riverside in 1981 and relocated in 1996 to San Diego, serving as founding Director of Molecular Immunology at the La Jolla Institute for Immunology.

In 2010, Dr. Ware joined Sanford Burnham Prebys with the goal of translating his patented discoveries of TNF-related cytokines and regulatory proteins of the immune system into new medicines. Dr. Ware organized several long-term partnerships with biotech and pharma companies to develop new therapeutics targeting inflammatory and autoimmune diseases. Success in translating fundamental knowledge into rational drug design led to the development of two novel therapeutics targeting inflammatory pathways, quisovalimab (anti-LIGHT antibody) in phase 2 clinical trials for COVID19 ARDS, asthma and Crohn’s Disease, and agonists to checkpoint inhibitory receptor, BTLA in autoimmune diseases.

Dr. Ware received the prestigious MERIT Award from the National Institutes of Health that provided the opportunity to develop translational research and drug development programs. Dr. Ware is recognized as a Distinguished Fellow of the American Association of Immunologists and served as the President and awarded Honorary Lifetime Membership in the International Cytokine and Interferon Society. The U.S. Patent and Trademark Office recognizes Dr. Ware as a ‘TNF Superfamily’ expert. He advises several biotechnology and pharmaceutical companies and serves on the SAB for the Arthritis National Research Foundation and the Allen Institute for Immunology.