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stories from the front lines of discovery
From scientific breakthroughs to new open‑source tools, the Allen Institute’s work is reshaping how science is done—and who it’s for. Explore the latest news, stories, and highlights from across our research, partnerships, and open science efforts.
AI BioDesign accelerator combines experimental biology and artificial intelligence to learn nature’s design rules
Researchers from the Allen Institute, University of Washington, and Fred Hutch Cancer Center, supported by Fund for Science and Technology, will build open AI models, datasets, and tools to accelerate biological design for health, sustainability, and other global challenges
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These rare human neurons generate electrical signals in two different cellular parts
With brain tissue samples donated by surgery patients come detailed descriptions of certain rare types of human cells - including new findings about...
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Q&A with the Allen Institute for Immunology’s first employee
Ernie Coffey started his career in science with a bang. It was 1997 and he landed a job at one of the institutes participating in the sequencing of...
immunology
news
Sped-up evolution may have molded the human brain by slowing neuron growth
Quickly evolving stretches of DNA unique to humans are important for brain development, a new study finds
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Brain scientists unveil wiring diagram containing 200,000 cells and nearly half billion connections in tiny piece of a mouse's brain
Detailed map captures 3D shapes of neurons and their synapses in stunning detail and is open to community for neuroscience and machine learning...
brain science
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To understand human cells, scientists look beyond genes
Deep dive into detailed images of human heart cells uncovers a disconnect between gene expression and cell structure
cell science
news
Science in Sixty | Shannon Reynolds
Figuring out how to transport live brain tissue from the operating room to the lab is challenging to say the least. In our latest Science in Sixty,...
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Study maps all the types of neurons across two major structures of the mouse brain
Cell-type parts list of the mouse neocortex and the hippocampal formation yields new information about how the mammalian brain evolved and develops
brain science
news
Science in Sixty | Brian Lee
Brian Lee, Ph.D., Senior Scientist at the Allen Institute for Brain Science, shares his journey from rebellious teen to crisis counselor to neuroscientist.
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New technique explores the ins and outs of our immune cells
Method that captures 3 different characteristics of individual human cells at once can shed light on aging and disease.
immunology
news
Allen Institute and BioMarin team up to develop gene therapies for rare brain diseases.
The collaboration leverages technologies intended to target gene expression to specific cells within the central nervous system
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Puget Sound Business Journal: Seattle biotech research hub launches with big goals for growth, scientific advances
The Seattle Hub for Synthetic Biology is developing technology to monitor genomic changes in cells in real time, in turn showing cells' whole histories and the genetic causes of disease.
Inside Precision Medicine: How Single-Cell Omics is Revolutionizing Our View Of Neurobiology
(Photo credit: miakievy / Getty Images) The adult human brain is made up of billions of neurons and glial cells. Understanding the diversity of these cells and their distinctive gene-regulatory mechanisms is crucial for determining how the brain works and, in turn, for developing treatments for neurologic disorders
GeekWire: Inside the new Seattle Hub for Synthetic Biology, which uses DNA to ‘record biology over time’
(Photo credit: Charlotte Schubert) Researchers opened the doors Monday to the new Seattle Hub for Synthetic Biology, a collaboration between the Allen Institute, the Chan Zuckerberg Initiative and the University of Washington.
Science Friday: 3,000 Types Of Brain Cells Categorized In Massive Brain Cell Atlas
In October 2023, an international group of scientists released an impressively detailed cell atlas of the human brain, published in 21 papers in the journals Science, Science Advances and Science Translational Medicine.
STAT: Allen Institute CEO Rui Costa on mapping the brain and paying early-career scientists decent salaries
Mapping the billions of cells that make up the brain is a task mammoth enough to keep hundreds of researchers across continents busy for years. But it’s just one of several ambitious projects the Allen Institute is helping tackle.
Scientific American: First Atlas of Every Mouse Brain Cell Could Improve Neuro Disease Treatments
Neuroscientists have unveiled their most comprehensive and detailed map of cell types across the entire mouse brain, delivering the latest results of a six-year-long scientific effort in which Seattle’s Allen Institute has played a leading role.
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