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stories from the front lines of discovery
From scientific breakthroughs to new open‑source tools, the Allen Institute’s work is reshaping how science is done—and who it’s for. Explore the latest news, stories, and highlights from across our research, partnerships, and open science efforts.
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AI BioDesign accelerator combines experimental biology and artificial intelligence to learn nature’s design rules

Researchers from the Allen Institute, University of Washington, and Fred Hutch Cancer Center, supported by Fund for Science and Technology, will build open AI models, datasets, and tools to accelerate biological design for health, sustainability, and other global challenges
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Look in the labs | Neural Dynamics
How do different brain regions connect and communicate? Researchers at the Allen Institute for Neural Dynamics are 3D imaging whole mouse brains in...
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Look in the labs | Cell Science
Cells are the building blocks of life.
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23 interns, 4 coffee machines, 1 summer: Through the eyes of this year’s cohort of budding science professionals
Allen Institute welcomes interns on-site for the first time since 2019 - these are some of their stories
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From 300,000 mouse neurons, scientists hope to glean how the brain drives behavior
New public dataset captures billions of electrical spikes from brains of animals trained to identify ‘oddball’ photos
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A prescription for exercise: Scientists want to help you find the best workout for your brain
Researchers are developing a fitness wearable to personalize exercise and lower the risks of dementia
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SciShots: clusters of Alzheimer’s cells
New data explores the cellular landscape of Alzheimer’s disease
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where does Alzheimer's begin?
pinpointing the cellular roots of Alzheimer's disease to find new targets for treatments and therapies
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Cell by cell, scientists are building a high-resolution map of brain changes in Alzheimer’s disease
A massive dataset of 1.2M brain cells shines a light on disease’s cellular roots
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DNA Typewriter keeps a record of cells’ long histories
Molecular recording device could be used to trace cell-by-cell growth of an entire animal
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SciShots: the 3D network inside a mouse’s brain
Scientists are piecing together the puzzle of the brain using light-sheet microscopy
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SciShots: brain tumors in high-res
scientists are using tumor “spheroids” to study glioblastoma, a deadly brain cancer
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SciShots: exploring cellular variability
Scientists are studying the wide range of “normal” within human cells
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media / GeekWire
Tech Moves: Allen Institute names new VP
Julie Harris has been appointed vice president of The Paul G. Allen Frontiers Group at the Seattle-based Allen Institute.
media / The Scientist
Charting the Human Immune Health Atlas
Every individual’s immune system is distinct and changes over time, affecting their health and disease response. Recently, researchers mapped human immune cells to explore what defines a healthy immune system across different ages.
media / The Transmitter
The Transmitter: Expanding set of viral tools targets almost any brain cell type
Harmless viruses that encase short noncoding DNA elements called enhancers enable cell-type-specific gene delivery across the central nervous system in rodents and primates.
media / NPR
NPR: Timeline shows what happens to different brain cells as Alzheimer’s progresses
An analysis of brains at various stages of Alzheimer's found that neurons called inhibitory neurons are the first to be affected by the disease.
media / Fox News
Fox News: New Alzheimer’s research reveals ‘quiet’ phase of the disease, before symptoms appear
Researchers led by the Allen Institute for Brain Science in Seattle and University of Washington Medicine have identified cellular changes in the brains of people with the disease — and a timeline of when they occur.
media / Newsweek
Newsweek: Alzheimer's Hidden 'Early' Brain Damage Phase Revealed by Neuroscientists
Alzheimer's disease damages the brain before any symptoms begin to appear, new research suggests. This is part of a new two-step model of Alzheimer's progression, which features an early "silent" stage of brain damage.
media / New York Times
New York Times: After a Decade, Scientists Unveil Fly Brain in Stunning Detail
(Photo credit: Tyler Sloan for FlyWire, Princeton University) Scientists have mapped out how 140,000 neurons are wired in the brain of the fruit fly, Drosophila melanogaster.
media / Nature
Nature: Largest brain map ever reveals fruit fly’s neurons in exquisite detail
(Photo credit: Tyler Sloan and Amy Sterling for FlyWire, Princeton University) “This is a huge deal,” says Clay Reid, a neurobiologist at the Allen Institute for Brain Science
media / New Scientist
NewScientist: Map of the immune system changing with age may help optimise vaccines
Our immune cells change a lot as the decades progress, which could explain why we become more susceptible to certain conditions
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