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Allen Institute discoveries, innovations, and open-source resources are transforming the scientific landscape and making progress possible. Read on for the latest news and highlights.

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Image of ovarian cancer cells and their invadopodia from a microscope

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Cellular yoga: Stretching cells to see a hidden world

02.29.2024

Allen Distinguished Investigators aim to stretch cancer cells like Silly Putty to reveal their elusive nutrients. 

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Black and white image of a fusion of silicone and human cells designed to mimic the heart’s mechanics.

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SciShots: A heart on a chip

02.14.2024

Heart cells hit a tiny “gym” to help scientists screen for toxic cancer drugs

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Composite image of science imagery from the 2023 Allen Distinguished Investigators

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The Paul G. Allen Family Foundation Awards $10.5 Million to new Allen Distinguished Investigators

11.21.2023

Research funding will support four projects focused on extracellular vesicles and three on sex hormones 

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Allen Discovery Center for Neuroimmune web header showing cells

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The Paul G. Allen Frontiers Group Announces Allen Discovery Center for Neuroimmune interactions at Icahn School of Medicine at Mount Sinai

11.09.2023

Multidisciplinary research center to define, map, and understand the health consequences of interactions between the nervous system and the immune...

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Comb jellies gives scientists hints of our nervous system’s past

08.29.2023

Ignored for a hundred years, comb jelly research is back in business

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Partial capture of a circle graph showing maximum lifespans of various mammalian species

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Aging is evolutionary, according to a new molecular ‘clock’ that predicts age in all mammals

08.14.2023

The first-of-its-kind clock could also be used to test rejuvenation therapies

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Image of mouse lungs

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SciShots: A tree-like mouse lung

08.07.2023

Scientists are learning the bartering system of two cell types to understand the lifecycle of a lung

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SciShots Blood Vessel

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SciShots: How to feed mini-organs

05.17.2023

Scientists are making lab-grown mini-organs more lifelike by adding blood vessels

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An astrocyte from the striatum

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SciShots: Star-shaped brain cells linked to OCD

04.26.2023

Mouse study finds disease-linked molecule influences the intricate, beautiful patterns of the brain cells known as astrocytes.

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The Paul G. Allen Frontiers Group Announces 16 New Allen Distinguished Investigators

12.15.2022

$10M in research funding will support cutting-edge projects in protein lifespan and nutrient sensing

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Star-shaped astrocytes in red surround an amyloid plaque in blue against a black background

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These brain cells named for stars contribute to Alzheimer’s

11.03.2022

Mouse study reveals many new types of cells known as astrocytes and narrows their role in neurodegenerative disease

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SciShots: The brain’s mysterious, multipurpose immune system

09.16.2022

Microglial cells act as the brain’s waste disposal when healthy — can they be manipulated to protect against disease?

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The Allen Institute’s bicycling group on their evening cycle in South Lake Union. Photo by Erik Dinnel / Allen Institute

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A prescription for exercise: Scientists want to help you find the best workout for your brain

08.09.2022

Researchers are developing a fitness wearable to personalize exercise and lower the risks of dementia

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DNA’s molecular wrinkles: Why you might be older or younger than you think

08.03.2022

‘Epigenetic clocks’ vary with disease and even by organ, but scientists are still trying to understand why

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illustration of type writer printing dna

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DNA Typewriter keeps a record of cells’ long histories

07.21.2022

Molecular recording device could be used to trace cell-by-cell growth of an entire animal

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SciShots: Glowing muscles of the comb jelly

05.27.2022

Biologists are studying the neurons and muscle cells of the ctenophore, a type of sea jelly that is the sister group to all other animals

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SciShots: How the brain plugs leaks

04.22.2022

A delicate molecular dance maintains the blood-brain barrier, protecting the brain while allowing transport of necessary resources

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A new technique developed by AHA-Allen Initiative-funded researchers at the Stanford University School of Medicine is shining light on the blood vessels that supply the brain. Illustration by Valentina Galata.

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A map of all our brains’ blood vessel cells finds new clues to Alzheimer’s disease

02.14.2022

Scientists release the first cell-by-cell atlas of the human blood-brain barrier.

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SciShots: A cell’s fate

02.11.2022

Synthetic biology is helping scientists understand development

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The Paul G. Allen Frontiers Group announces 23 new Allen Distinguished Investigators

02.09.2022

$15.5M in research funding will support cutting-edge projects in mammalian synthetic biology, the neuroscience of under-studied animals, and tiny...

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