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Allen Institute discoveries, innovations, and open-source resources are transforming the scientific landscape and making progress possible. Read on for the latest news and highlights.

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SciShots: Who talks to the visual part of the brain?

12.22.2022

Technique built off rabies virus lets scientists trace backward flow of neural activity in the mouse brain

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Allen Institute Announces 2022 Next Generation Leaders

12.08.2022

Six early-career neuroscientists will help guide research into the complexities of the mammalian brain

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The many branching tendrils of a mouse oligodendrocyte precursor cell, a type of brain cell that appears to play many roles in the brain. A study from the Allen Institute highlights a newly discovered role for this kind of cell. Image by JoAnn Buchanan, Ph.D.

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Scientists capture detailed snapshots of mouse brain cells nibbling on neurons

11.28.2022

3D structures of cells and connections reveal new role for an understudied brain cell

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A researcher at the Allen Institute for Brain Science prepares a piece of live human brain tissue. Photo by Erik Dinnel / Allen Institute

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How do human neurons respond to psychedelics?

11.12.2022

Neuroscientists send live human brain samples on a trip to glean insights into consciousness, therapy for depression and anxiety

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Lake Conferences

11.09.2022

In circuit neuroscience

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SciShots: Brain-o-lantern

10.31.2022

Quality control spies a spooky brain

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SciShots: The Brain’s Cleanup Crew and Paramedics

10.14.2022

The shape-shifting microglia play a vital role in maintaining brain health

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SciShots: The brain’s mysterious, multipurpose immune system

09.16.2022

Microglial cells act as the brain’s waste disposal when healthy — can they be manipulated to protect against disease?

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Video

Where does Alzheimer’s begin?

07.29.2022

Pinpointing the cellular roots of Alzheimer's disease to find new targets for treatments and therapies.

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SciShots: The 3D network inside a mouse’s brain

07.08.2022

Scientists are piecing together the puzzle of the brain using light-sheet microscopy

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SciShots: Brain tumors in high-res

06.30.2022

Scientists are using tumor “spheroids” to study glioblastoma, a deadly brain cancer

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Podcast

Lab Notes | Building a consciousness meter with Christof Koch

05.26.2022

Can we put a number on human consciousness?

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Four different kinds of brain cells are shown in high resolution. A large green neuron in the center is surrounded by different kinds of brain cells in purple, gold and pink.

Science Images

SciShots: A quartet of brain cells

05.20.2022

Scientists are sifting through the hundreds of thousands of brain cells present in a cubic millimeter of mouse brain

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Allen Institute neuroscientist Xana Waughman describes recordings of mouse neuron activity — in a technique known as 2-photon microscopy, scientists are able to capture neurons switching on and off through a fluorescent sensor engineered to light up with cellular activity. This technique is one of those used in OpenScope, a shared brain observatory program at the Allen Institute.

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New research to understand how the brain handles optical illusions and makes predictions

05.09.2022

3 new projects launch on OpenScope, a shared neuroscience observatory

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Illustration by Jenny Burns / Allen Institute

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Why is the human brain so difficult to understand? We asked 4 neuroscientists.

04.21.2022

Thoughts, memories, sensations — why are we still in the dark about how they work?

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For Brain Awareness Week 2022, we dropped in on five Allen Institute teams working to understand the brain. Get a glimpse into their workdays.

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A day in the (neuroscience) life: OpenScope

03.18.2022

Scientists on the OpenScope team help share the Allen Institute’s ‘observatory of the mind’ with the larger scientific community

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Allen Institute for Brain Science researchers are working to develop a parts list, or “periodic table,” of cell types in the brain. Image by Benedicte Rossi.

Video

Cell Type Knowledge Explorer

03.17.2022

Examine multimodal data from thousands of cells across three mammalian species with the Cell Type Knowledge Explorer

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A day in the (neuroscience) life: Electron microscopy

03.17.2022

Researchers on the EM team are viewing the brain in unprecedented detail

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Video

Science in Sixty | Luke Campagnola

03.16.2022

When Luke Campagnola isn't investigating the complexities of mammalian brain circuitry, he's spending time with family and practicing parkour.

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A day in the (neuroscience) life: Human cell types

03.16.2022

Scientists in this laboratory are exploring the molecular details of human — and other primate — brain cells

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