goals and approach
The Integrated Cell Physiology team at the Allen Institute's brain science accelerator conducts Patch-seq experiments using a whole-cell patch clamp technique to establish connections between morphoelectric characteristics and transcriptomic-defined cell types. This research helps to bridge the gap between genotype and phenotype.
The efficient and automated pipeline developed by this team is generating high-quality large-scale data at rates previously deemed impractical for electrophysiology experiments. Investigators on the Integrated Cell Physiology team utilize animal models and human tissue specimens acquired through neurosurgical procedures in combination with state-of-the-art genetic tools to identify rare cell types.
