Shendure Lab

Developing new technologies and methods for genetics, genomics, and molecular biology for next-generation DNA sequencing to measure biological phenomena.

The Seattle Hub for Synthetic Biology is a collaboration between Allen Institute, Chan Zuckerberg Initiative and the University of Washington.

Goals and Approach

The Shendure Lab is part of the Howard Hughes Medical Institute and the Department of Genome Sciences at the University of Washington (Seattle, WA). The mission of our lab is to develop and apply new technologies and methods for genetics, genomics and molecular biology. Most of our work exploits next-generation DNA sequencing which is effectively emerging as a broadly enabling microscope for the measurement of biological phenomena. Our ongoing work generally falls into six areas. These are listed below as links to representative publications in each area.

Developing New Molecular Methods
Genomic Approaches to Developmental Biology
Massively Parallel Functional Genomics
Translating Genomics to the Clinic
Genetic Basis of Human Disease
Genome Sequencing Technologies

(Photo credit: Ron Wurzer/AP Images for HHMI) Dr. Jay Shendure, Executive Director of the Seattle Hub for Synthetic Biology and a professor of genome sciences and Scientific Director of the Brotman Baty Institute at the University of Washington School of Medicine

Research Details

Molecular recording during human development (Haedong, Jenny)

We aim to record molecular events during human tissue development onto the genome using DNA typewriter. This will uncover cellular histories that are critical for dynamic developmental processes.

The Shendure Lab Team

Learn even more about the Shendure Lab at our website.

Shendure Lab Website