Goals and Approach

The Multi-scale Molecular Anatomy group at the Allen Institute for Neural Dynamics aims to generate comprehensive descriptions of neuronal types and examine connectivity at various scales in defined cell types. Using large-scale microscopy methods, this group is working to identify projection neuron types based on the structure of single neurons. This morphological data will be combined with spatial transcriptomics to uncover new morpho-molecular cell types. Finally, they are using super-resolution immunofluorescence imaging methods to study postsynaptic targets of these cells. Analysis of the wiring in the mouse brain will create foundational data sets to examine complex behaviors at the level of defined neuronal types.