Bio:

Marshall S. Horwitz, M.D., Ph.D., Professor of Pathology, Medicine, and Genome Sciences at the University of Washington and an Allen Distinguished Investigator, is a physician-scientist whose research focuses on the hereditary basis of bone marrow failure and malignancy while building on their molecular genetic pathogenesis in order to elucidate development at a single cell level. He received his bachelor’s degree in Chemistry from Revelle College at UCSD and is a graduate of the University of Washington M.D./Ph.D. program (MSTP), which he now directs. For his dissertation research with Dr. Lawrence Loeb, he was among the first to develop Directed Evolution and cofounded the biotech firm Darwin Molecular, which identified genes responsible for early onset Alzheimer Disease (PSEN2), premature aging (WRN), and T cell development (FOXP3).

He completed postdoctoral training in developmental biology with the late Dr. Harold Weintraub at Fred Hutchinson Cancer Research Center. His laboratory is responsible for the clinical and molecular genetic discovery and definition of hereditary neutropenia due to mutations in ELANE and other genes, and of familial leukemia syndromes resulting from mutations in GATA2 and other transcription factors. His honors include the Presidential Early Career Award (PECASE), NIH Director’s Pioneer Award, and election to the American Society for Clinical Investigation (ASCI) and Association of American Physicians (AAP).