
Bio:
Jack Waters is an Associate Investigator in the Neural Coding group. He leads a team who investigate the cellular and circuit mechanisms underlying changes in cortical physiology with behavior. Before joining the Allen Institute for Brain Science, he held postdoctoral positions at Stanford University and the Max Planck Institute for Medical Research in Heidelberg, Germany, and was an Assistant Professor in the Department of Physiology at Northwestern University in Chicago. Previous research includes pioneering the combination of electrophysiology and 2-photon imaging techniques to study cells and circuits in intact rodents and examining how ongoing synaptic activity modulates the excitability of neocortical pyramidal neurons in vivo. He also developed the application of optogenetics to control the release of acetylcholine in neocortex and established that nicotinic acetylcholine receptors play a large role in shaping the effects of acetylcholine on neocortical pyramidal neurons. Waters holds a BSc in Biochemistry from the University of York and a PhD in Pharmacology from University College London.
Publications
Nature Neuroscience
Integrated multimodal cell atlas of Alzheimer's disease
Oct 14, 2024
Mariano I. Gabitto, Kyle J. Travaglini, Victoria M. Rachleff, Eitan S. Kaplan, Brian Long, Jeanelle Ariza, Yi Ding, Joseph T. Mahoney, Nick Dee, Jeff Goldy, Erica J. Melief, Anamika Agrawal, Omar Kana, Xingjian Zhen, Samuel T. Barlow, Krissy Brouner, Jazmin Campos, John Campos, Ambrose J. Carr, Tamara Casper, Rushil Chakrabarty, Michael Clark, Jonah Cool, Rachel Dalley, Martin Darvas, Song-Lin Ding, Tim Dolbeare, Tom Egdorf, Luke Esposito, Rebecca Ferrer, Lynn E. Fleckenstein, Rohan Gala, Amanda Gary, Emily Gelfand, Jessica Gloe, Nathan Guilford, Junitta Guzman, Daniel Hirschstein, Windy Ho, Madison Hupp, Tim Jarsky, Nelson Johansen, Brian E. Kalmbach, Lisa M. Keene, Sarah Khawand, Mitchell D. Kilgore, Amanda Kirkland, Michael Kunst, Brian R. Lee, Mckaila Leytze, Christine L. Mac Donald, Jocelin Malone, Zoe Maltzer, Naomi Martin, Rachel McCue, Delissa McMillen, Gonzalo Mena, Emma Meyerdierks, Kelly P. Meyers, Tyler Mollenkopf, Mark Montine, Amber L. Nolan, Julie K. Nyhus, Paul A. Olsen, Maiya Pacleb, Chelsea M. Pagan, Nicholas Peña, Trangthanh Pham, Christina Alice Pom, Nadia Postupna, Christine Rimorin, Augustin Ruiz, Giuseppe A. Saldi, Aimee M. Schantz, Nadiya V. Shapovalova, Staci A. Sorensen, Brian Staats, Matt Sullivan, Susan M. Sunkin, Carol Thompson, Michael Tieu, Jonathan T. Ting, Amy Torkelson, Tracy Tran, Nasmil J. Valera Cuevas, Sarah Walling-Bell, Ming-Qiang Wang, Jack Waters, Angela M. Wilson, Ming Xiao, David Haynor, Nicole M. Gatto, Suman Jayadev, Shoaib Mufti, Lydia Ng, Shubhabrata Mukherjee, Paul K. Crane, Caitlin S. Latimer, Boaz P. Levi, Kimberly A. Smith, Jennie L. Close, Jeremy A. Miller, Rebecca D. Hodge, Eric B. Larson, Thomas J. Grabowski, Michael Hawrylycz, C. Dirk Keene, Ed S. Lein
Read MoreNature
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Dec 01, 2023
Zizhen Yao, Cindy T. J. van Velthoven, Michael Kunst, Meng Zhang, Delissa McMillen, Changkyu Lee, Won Jung, Jeff Goldy, Aliya Abdelhak, Matthew Aitken, Katherine Baker, Pamela Baker, Eliza Barkan, Darren Bertagnolli, Ashwin Bhandiwad, Cameron Bielstein, Prajal Bishwakarma, Jazmin Campos, Daniel Carey, Tamara Casper, Anish Bhaswanth Chakka, Rushil Chakrabarty, Sakshi Chavan, Min Chen, Michael Clark, Jennie Close, Kirsten Crichton, Scott Daniel, Peter DiValentin, Tim Dolbeare, Lauren Ellingwood, Elysha Fiabane, Timothy Fliss, James Gee, James Gerstenberger, Alexandra Glandon, Jessica Gloe, Joshua Gould, James Gray, Nathan Guilford, Junitta Guzman, Daniel Hirschstein, Windy Ho, Marcus Hooper, Mike Huang, Madie Hupp, Kelly Jin, Matthew Kroll, Kanan Lathia, Arielle Leon, Su Li, Brian Long, Zach Madigan, Jessica Malloy, Jocelin Malone, Zoe Maltzer, Naomi Martin, Rachel McCue, Ryan McGinty, Nicholas Mei, Jose Melchor, Emma Meyerdierks, Tyler Mollenkopf, Skyler Moonsman, Thuc Nghi Nguyen, Sven Otto, Trangthanh Pham, Christine Rimorin, Augustin Ruiz, Raymond Sanchez, Lane Sawyer, Nadiya Shapovalova, Noah Shepard, Cliff Slaughterbeck, Josef Sulc, Michael Tieu, Amy Torkelson, Herman Tung, Nasmil Valera Cuevas, Shane Vance, Katherine Wadhwani, Katelyn Ward, Boaz Levi, Colin Farrell, Rob Young, Brian Staats, Ming-Qiang Michael Wang, Carol L. Thompson, Shoaib Mufti, Chelsea M. Pagan, Lauren Kruse, Nick Dee, Susan M. Sunkin, Luke Esposito, Michael J. Hawrylycz, Jack Waters, Lydia Ng, Kimberly Smith, Bosiljka Tasic, Xiaowei Zhuang, Hongkui Zeng
Read MoreScience (New York, N.Y.)
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Oct 13, 2023
Brian R. Lee, Rachel Dalley, Jeremy A. Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, Lindsay Ng, Lauren Alfiler, Katherine Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Eva Csajbok, Nicholas Donadio, Stan L. W. Driessens, Tom Egdorf, Rachel Enstrom, Anna A. Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S. Heistek, Dijon Hill, Wen-Hsien Hou, Nelson Johansen, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela León, Brian Long, Matthew Mallory, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica J. Melief, Gabor Molnar, Marty T. Mortrud, Dakota Newman, Julie Nyhus, Ximena Opitz-Araya, Attila Ozsvár, Trangthanh Pham, Alice Pom, Lydia Potekhina, Ram Rajanbabu, Augustin Ruiz, Susan M. Sunkin, Ildikó Szöts, Naz Taskin, Bargavi Thyagarajan, Michael Tieu, Jessica Trinh, Sara Vargas, David Vumbaco, Femke Waleboer, Sarah Walling-Bell, Natalie Weed, Grace Williams, Julia Wilson, Shenqin Yao, Thomas Zhou, Pál Barzó, Trygve Bakken, Charles Cobbs, Nick Dee, Richard G. Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W. Gouwens, Benjamin Grannan, Ryder P. Gwinn, Jason S. Hauptman, Rebecca Hodge, Tim Jarsky, C. Dirk Keene, Andrew L. Ko, Anders Rosendal Korshoej, Boaz P. Levi, Kaare Meier, Jeffrey G. Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L. Silbergeld, Kimberly Smith, Jens Christian Sørensen, Jack Waters, Hongkui Zeng, Jim Berg, Marco Capogna, Natalia A. Goriounova, Brian Kalmbach, Christiaan P. J. de Kock, Huib D. Mansvelder, Staci A. Sorensen, Gabor Tamas, Ed S. Lein, Jonathan T. Ting
Read MoreScience (New York, N.Y.)
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Oct 13, 2023
Thomas Chartrand, Rachel Dalley, Jennie Close, Natalia A. Goriounova, Brian R. Lee, Rusty Mann, Jeremy A. Miller, Gabor Molnar, Alice Mukora, Lauren Alfiler, Katherine Baker, Trygve E. Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, Krissy Brouner, Tamara Casper, Eva Adrienn Csajbok, Nick Dee, Tom Egdorf, Rachel Enstrom, Anna A. Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S. Heistek, DiJon Hill, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela Leon, Brian Long, Matthew Mallory, Medea McGraw, Delissa McMillen, Erica J. Melief, Norbert Mihut, Lindsay Ng, Julie Nyhus, Gáspár Oláh, Attila Ozsvár, Victoria Omstead, Zoltan Peterfi, Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Marton Rozsa, Augustin Ruiz, Joanna Sandle, Susan M. Sunkin, Ildiko Szots, Michael Tieu, Martin Toth, Jessica Trinh, Sara Vargas, David Vumbaco, Grace Williams, Julia Wilson, Zizhen Yao, Pal Barzo, Charles Cobbs, Richard G. Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W. Gouwens, Benjamin Grannan, Ryder P. Gwinn, Jason S. Hauptman, Tim Jarsky, C. Dirk Keene, Andrew L. Ko, Christof Koch, Jeffrey G. Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L. Silbergeld, Kimberly Smith, Staci A. Sorensen, Bosiljka Tasic, Jonathan T. Ting, Jack Waters, Christiaan P. J. de Kock, Huib D. Mansvelder, Gabor Tamas, Hongkui Zeng, Brian Kalmbach, Ed S. Lein
Read MoreStroke
Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia
May 01, 2023
Stefan Stamenkovic, Yuandong Li, Jack Waters, Andy Shih
Read MoreCell Reports
Laminar distribution and arbor density of two functional classes of thalamic inputs to primary visual cortex
Oct 12, 2021
Jun Zhuang, Yun Wang, Naveen D. Ouellette, Emily E. Turschak, Rylan S. Larsen, Kevin T. Takasaki, Tanya L. Daigle, Bosiljka Tasic, Jack Waters, Hongkui Zeng, R. Clay Reid
Read MoreeLife
Relationship between simultaneously recorded spiking activity and fluorescence signal in GCaMP6 transgenic mice
Mar 08, 2021
Lawrence Huang, Peter Ledochowitsch, Ulf Knoblich, Jérôme Lecoq, Gabe J. Murphy, R. Clay Reid, Saskia Ej de Vries, Christof Koch, Hongkui Zeng, Michael A. Buice, Jack Waters, Lu Li
Read MoreeNeuro
The Effect of Inclusion Criteria on the Functional Properties Reported in Mouse Visual Cortex
Feb 01, 2021
Natalia Mesa, Jack Waters, Saskia E. J. de Vries
Read MoreeNeuro
Superficial Bound of the Depth Limit of Two-Photon Imaging in Mouse Brain
Jan 01, 2020
Kevin Takasaki, Reza Abbasi-Asl, Jack Waters
Read MoreNature Neuroscience
A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex
Jan 01, 2020
Saskia E. J. de Vries, Jerome A. Lecoq, Michael A. Buice, Peter A. Groblewski, Gabriel K. Ocker, Michael Oliver, David Feng, Nicholas Cain, Peter Ledochowitsch, Daniel Millman, Kate Roll, Marina Garrett, Tom Keenan, Leonard Kuan, Stefan Mihalas, Shawn Olsen, Carol Thompson, Wayne Wakeman, Jack Waters, Derric Williams, Chris Barber, Nathan Berbesque, Brandon Blanchard, Nicholas Bowles, Shiella D. Caldejon, Linzy Casal, Andrew Cho, Sissy Cross, Chinh Dang, Tim Dolbeare, Melise Edwards, John Galbraith, Nathalie Gaudreault, Terri L. Gilbert, Fiona Griffin, Perry Hargrave, Robert Howard, Lawrence Huang, Sean Jewell, Nika Keller, Ulf Knoblich, Josh D. Larkin, Rachael Larsen, Chris Lau, Eric Lee, Felix Lee, Arielle Leon, Lu Li, Fuhui Long, Jennifer Luviano, Kyla Mace, Thuyanh Nguyen, Jed Perkins, Miranda Robertson, Sam Seid, Eric Shea-Brown, Jianghong Shi, Nathan Sjoquist, Cliff Slaughterbeck, David Sullivan, Ryan Valenza, Casey White, Ali Williford, Daniela M. Witten, Jun Zhuang, Hongkui Zeng, Colin Farrell, Lydia Ng, Amy Bernard, John W. Phillips, R. Clay Reid, Christof Koch
Read MoreBiomedical Optics Express
Dual-plane 3-photon microscopy with remote focusing
Nov 01, 2019
Kevin T. Takasaki, Dmitri Tsyboulski, Jack Waters
Read MorePloS One
Identification of genetic markers for cortical areas using a Random Forest classification routine and the Allen Mouse Brain Atlas
Jan 01, 2019
Natalie Weed, Trygve Bakken, Nile Graddis, Nathan Gouwens, Daniel Millman, Michael Hawrylycz, Jack Waters
Read MorePloS One
Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse
Jan 01, 2019
Jack Waters, Eric Lee, Nathalie Gaudreault, Fiona Griffin, Jerome Lecoq, Cliff Slaughterbeck, David Sullivan, Colin Farrell, Jed Perkins, David Reid, David Feng, Nile Graddis, Marina Garrett, Yang Li, Fuhui Long, Chris Mochizuki, Kate Roll, Jun Zhuang, Carol Thompson
Read MorePLoS computational biology
Visual physiology of the layer 4 cortical circuit in silico
Nov 01, 2018
Anton Arkhipov, Nathan W. Gouwens, Yazan N. Billeh, Sergey Gratiy, Ramakrishnan Iyer, Ziqiang Wei, Zihao Xu, Reza Abbasi-Asl, Jim Berg, Michael Buice, Nicholas Cain, Nuno da Costa, Saskia de Vries, Daniel Denman, Severine Durand, David Feng, Tim Jarsky, Jérôme Lecoq, Brian Lee, Lu Li, Stefan Mihalas, Gabriel K. Ocker, Shawn R. Olsen, R. Clay Reid, Gilberto Soler-Llavina, Staci A. Sorensen, Quanxin Wang, Jack Waters, Massimo Scanziani, Christof Koch
Read MoreCell
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality
Jul 12, 2018
Tanya L. Daigle, Linda Madisen, Travis A. Hage, Matthew T. Valley, Ulf Knoblich, Rylan S. Larsen, Marc M. Takeno, Lawrence Huang, Hong Gu, Rachael Larsen, Maya Mills, Alice Bosma-Moody, La' Akea Siverts, Miranda Walker, Lucas T. Graybuck, Zizhen Yao, Olivia Fong, Thuc Nghi Nguyen, Emma Garren, Garreck H. Lenz, Mariya Chavarha, Julie Pendergraft, James Harrington, Karla E. Hirokawa, Julie A. Harris, Philip R. Nicovich, Medea J. McGraw, Douglas R. Ollerenshaw, Kimberly A. Smith, Christopher A. Baker, Jonathan T. Ting, Susan M. Sunkin, Jérôme Lecoq, Michael Z. Lin, Edward S. Boyden, Gabe J. Murphy, Nuno M. da Costa, Jack Waters, Lu Li, Bosiljka Tasic, Hongkui Zeng
Read MoreBio-Protocol
Registration and Alignment Between in vivo Functional and Cytoarchitectonic Maps of Mouse Visual Cortex
Feb 20, 2018
Jun Zhuang, Quanxin Wang, Marc Takeno, Jack Waters
Read MoreFrontiers in Neural Circuits
Neuromodulatory Correlates of Pupil Dilation
Jan 01, 2018
Rylan S. Larsen, Jack Waters
Read MoreeNeuro
Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
Oct 01, 2017
Nicholas A. Steinmetz, Christina Buetfering, Jerome Lecoq, Christian R. Lee, Andrew J. Peters, Elina A. K. Jacobs, Philip Coen, Douglas R. Ollerenshaw, Matthew T. Valley, Saskia E. J. de Vries, Marina Garrett, Jun Zhuang, Peter A. Groblewski, Sahar Manavi, Jesse Miles, Casey White, Eric Lee, Fiona Griffin, Joshua D. Larkin, Kate Roll, Sissy Cross, Thuyanh V. Nguyen, Rachael Larsen, Julie Pendergraft, Tanya Daigle, Bosiljka Tasic, Carol L. Thompson, Jack Waters, Shawn Olsen, David J. Margolis, Hongkui Zeng, Michael Hausser, Matteo Carandini, Kenneth D. Harris
Read MoreeLife
An extended retinotopic map of mouse cortex
Jan 06, 2017
Jun Zhuang, Lydia Ng, Derric Williams, Matthew Valley, Yang Li, Marina Garrett, Jack Waters
Read MoreProceedings of the National Academy of Sciences of the United States of America
Inferring cortical function in the mouse visual system through large-scale systems neuroscience
Jul 05, 2016
Michael Hawrylycz, Costas Anastassiou, Anton Arkhipov, Jim Berg, Michael Buice, Nicholas Cain, Nathan W. Gouwens, Sergey Gratiy, Ramakrishnan Iyer, Jung Hoon Lee, Stefan Mihalas, Catalin Mitelut, Shawn Olsen, R. Clay Reid, Corinne Teeter, Saskia de Vries, Jack Waters, Hongkui Zeng, Christof Koch, MindScope
Read MorePloS One
Characterization of Channelrhodopsin and Archaerhodopsin in Cholinergic Neurons of Cre-Lox Transgenic Mice
Jan 01, 2016
Tristan Hedrick, Bethanny Danskin, Rylan S. Larsen, Doug Ollerenshaw, Peter Groblewski, Matthew Valley, Shawn Olsen, Jack Waters
Read MorePloS One
Optogenetics in Mice Performing a Visual Discrimination Task: Measurement and Suppression of Retinal Activation and the Resulting Behavioral Artifact
Jan 01, 2015
Bethanny Danskin, Daniel Denman, Matthew Valley, Douglas Ollerenshaw, Derric Williams, Peter Groblewski, Clay Reid, Shawn Olsen, Timothy Blanche, Jack Waters
Read More