Team

Staff Profiles

Greg Szeto, Ph.D.

Assistant Investigator

greg.szeto@alleninstitute.org

Greg is an Assistant Investigator in Experimental Immunology at the Allen Institute for Immunology, joining in March 2020. He firmly believes in the transformative power of big data and team science. Greg is focused on discovering novel mechanistic insights into the function of the human immune system in health and disease, aiming to improve clinical outcomes and develop next-generation therapies.  

Previously Greg was an Assistant Professor in Chemical, Biochemical, and Environmental Engineering at UMBC and the Tumor Immunology and Immunotherapy Program at the University of Maryland Greenebaum Comprehensive Cancer Center. His lab with Dr. Bob Varelas at Boston University defined the protein YAP as a novel immunosuppressive factor in T cells with applications to cancer immunotherapy. Other major projects included a novel platform for rapid and scalable immune cell engineering, nanoparticles for enhanced drug delivery in lupus, and systems immunology studies to define mechanistic and predictive models of traumatic brain injury and cancer immunotherapy. 

At MIT’s Koch Institute and the Ragon Institute, Greg was an NCI F32 postdoctoral fellow training at the interface of immunology, systems biology, and engineering with Dr. Darrell Irvine and Dr. Doug Lauffenburger. Leveraging interdisciplinary collaborations, he led projects using systems approaches to model cytokine networks in HIV and cancer immunotherapies, developed multiple single-cell platforms to interrogate immune cells, and advanced multiple engineered immunotherapies for cancer, HIV eradication, and vaccines.  These included a new antigen delivery method for B cell-based vaccines licensed to SQZ Biotech and Roche. Currently, this vaccine is in phase 1 clinical trials for HPV+ cancers. Greg earned his PhD in Cellular and Molecular Medicine from Johns Hopkins University School of Medicine. His thesis with Dr. Janice Clements defined the immunomodulatory and anti-HIV mechanisms of minocycline in human CD4+ T cells and plasmacytoid dendritic cells, demonstrating its potential as an adjunct to HAART. Greg received dual BS degrees in Chemical and Biomedical & Health Engineering from Carnegie Mellon. 

Expertise

  • Immunology
  • Virology
  • Cancer immunotherapy
  • Infectious diseases
  • Systems biology
  • Bioengineering
  • Vaccines
  • Drug delivery

Research Programs

  • Experimental Immunology
  • Computational Biology
  • Molecular Biology 

Expertise

  • Immunology
  • Virology
  • Cancer immunotherapy
  • Infectious diseases
  • Systems biology
  • Bioengineering
  • Vaccines
  • Drug delivery

Research Programs

  • Experimental Immunology
  • Computational Biology
  • Molecular Biology 

Selected Publications View Publications

Lipid-mediated insertion of Toll-like receptor (TLR) ligands for facile immune cell engineering

Frontiers in Immunology
April 22, 2020

Zhang MH, Slaby E, Stephanie G, Yu C, Watts DM, Liu H, Szeto GL

Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits

Journal of Neuroscience
April 1, 2020

Henry RJ, Ritzel RM, Barrett JP, Doran SJ, Jiao Y, Leach JB, Szeto GL, Stoica BA, Faden AI, Loane DJ

Yap suppresses T-cell function and infiltration in the tumor microenvironment

PLoS Biology
January 1, 2020

Stampouloglou E, Cheng N, Federico A, Slaby E, Monti S, Szeto GL, Varelas X

Integrative Approaches to Cancer Immunotherapy

Trends in Cancer
July 1, 2019

Szeto GL, Finley SD