AHA-Allen Initiative

AHA-Allen Initiative Team led by Mukesh K. Jain, M.D.

AHA-Allen Initiative Team at University Hospitals Cleveland Medical Center

Mukesh K. Jain, M.D., a cardiologist at University Hospitals Cleveland Medical Center and Professor of Medicine at Case Western Reserve University School of Medicine, will lead a team of investigators from University Hospitals Cleveland Medical Center, Johns Hopkins University, and University of Pennsylvania in a four-year project to explore how red blood cells, the most abundant cells in our body, and the inner lining of small blood vessels called endothelium work together as a unit to drive brain health and age-related cognitive disease. This unit of blood cells and blood vessels controls the delivery of oxygen and nutrients to our brain every second we are alive. Jain and his team will examine how connections between the red blood cells, blood vessels and the brain are altered during aging and disease and will test whether new therapeutics can restore the proper connections. 

Mukesh K. Jain, M.D.

Dr. Jain is Chief Academic Officer, University Hospitals Health System; Chief Scientific Officer, University Hospitals Harrington Discovery Institute; the Ellery Sedgwick Jr. Chair & Distinguished Scientist; Vice Dean for UH Hospitals Affairs and Professor of Medicine, Case Western Reserve University School of Medicine; and the Visiting Professor, University of Oxford. 

Dr. Jain is widely recognized for pioneering studies establishing KLF proteins as nodal regulators of metabolism, immunity, and aging. He has translated this work from animals to humans and established KLFs as key pharmacologic targets for therapeutic gain. His work has been published in top-tier peer-reviewed journals and he has been continuously supported for 17 years through funding from the National Institutes of Health (including the Outstanding Investigator Award), American Heart Association (including the Established Investigator Award), the Paul G. Allen Frontiers Group, Leducq Foundation, and diverse philanthropic organizations.

Dr. Jain’s academic contributions are recognized by numerous awards and honors, including election to the National Academy of Medicine (NAM, 2016), the American Association of Physicians (AAP, 2009), and the American Society for Clinical Investigation (ASCI, 2005). He is the 2015 recipient of the Judah Folkman Award in Vascular Biology from North American Vascular Biology Organization and the 2012 recipient of the American Heart Association’s Honorary Russell Ross Memorial Lectureship in Vascular Biology. Dr. Jain is a member of the American Heart Association’s Advancement of Science and Basic Science Council, and the National Heart, Lung, and Blood Institute (NHLBI) Board of External Experts. He is a past President of the American Society for Clinical Investigation, one of the oldest honorific physician societies in the country. He is a gifted mentor with mentorship awards from Harvard Medical School and University Hospitals/Case Western Reserve University.