AHA-Allen Initiative

AHA-Allen Initiative Team led by Mukesh K. Jain, M.D.

AHA-Allen Initiative Team at University Hospitals Cleveland Medical Center

Mukesh K. Jain, M.D., a cardiologist at University Hospitals Cleveland Medical Center and Professor of Medicine at Case Western Reserve University School of Medicine, will lead a team of investigators from University Hospitals Cleveland Medical Center, Johns Hopkins University, and University of Pennsylvania in a four-year project to explore how red blood cells, the most abundant cells in our body, and the inner lining of small blood vessels called endothelium work together as a unit to drive brain health and age-related cognitive disease. This unit of blood cells and blood vessels controls the delivery of oxygen and nutrients to our brain every second we are alive. Jain and his team will examine how connections between the red blood cells, blood vessels and the brain are altered during aging and disease and will test whether new therapeutics can restore the proper connections. 

Mukesh K. Jain, M.D.

Dr. Jain is Chief Scientific Officer, University Hospitals Health System, Chief Research Officer, University Hospitals Harrington Heart & Vascular Institute; the Ellery Sedgwick Jr. Chair & Distinguished Scientist; and Vice Dean for Medical Sciences and Professor of Medicine, Case Western Reserve University School of Medicine.  

Dr. Jain is internationally recognized for studies that established a central role for a family of transcription factors termed Kruppel-like factors, or KLFs, in cardiovascular biology, innate immunity, and metabolism. He has translated this work into animals and humans and demonstrated that KLFs are viable targets for therapeutic gain.  

Dr. Jain’s academic contributions are recognized by numerous awards and honors, including election to the National Academy of Medicine, the American Society for Clinical Investigation, American Association of Physicians, and Association of University Cardiologists. He is the 2015 recipient of the Judah Folkman Award in Vascular Biology from North American Vascular Biology Organization. Dr. Jain is a member of the American Heart Association’s Advancement of Science and Basic Science Council, and the National Heart, Lung, and Blood Institute (NHLBI) Board of External Experts. He is recipient of numerous grants, including the NHLBI Outstanding Investigator Award and the American Heart Association’s Established Investigator Award. He is a past president of the American Society for Clinical Investigation. He is a gifted mentor with mentorship awards from Harvard Medical School and Case Western Reserve University/University Hospitals Health System.