Brain Awareness Week 2022

Brain Awareness Week: Understanding the Cellular Roots of Alzheimer’s Disease

Alzheimer’s disease is a common form of dementia that leads to devastating cognitive and neurological deficits. However, despite affecting an estimated 6.2 million adults in the US alone in 2021, its causes are poorly understood and no effective treatments exist to halt or reverse the neuron death caused by the disease. How the disease starts — and what happens in single cells across the brain as the disease progresses — is similarly unknown. Research at the Allen Institute for Brain Science and elsewhere on the types of cells that make up the human brain has applications for understanding what is happening in Alzheimer’s.

Webinar details

Wednesday, March 9, 2022
4:00-5:00pm Pacific Time

View on Youtube

At this webinar, learn about the challenges physicians face in treating Alzheimer’s disease, what happens to the brain in patients with this disease, and current research on cell types in healthy and diseased human brains.

This free webinar is geared towards members of the general public who are interested in learning more about Alzheimer’s disease, cell types in neuroscience, and current research in both areas. The presenters will not assume any prior knowledge of the neuroscience of Alzheimer’s or cell types. This event is also suitable for students at the high school level and above.

Event overview     Featured speakers     View on Youtube

This webinar is presented by members of the Alzheimer’s center at the Allen Institute for Brain Science, an NIH-supported collaboration between the Allen Institute for Brain Science, University of Washington Medicine, and Kaiser Permanente Washington Health Research Group. Its goal is to apply the methods and understanding of cell types developed in part at the Allen Institute for Brain Science to Alzheimer’s disease, particularly in the early stages of the disease and to identifying potential therapy targets.

Brain Awareness Week, sponsored by the Dana Foundation, is a worldwide campaign to develop public awareness, knowledge, and enthusiasm about the brain and neuroscience. Learn more at brainawareness.org.

Event overview

  • Introduction: Ed Lein, Ph.D.

  • Clinical challenges of Alzheimer's disease: Kimiko Domoto-Reilly, M.D.

  • Neuropathology of Alzheimer's disease: Caitlin Latimer, M.D., Ph.D.

  • Introduction to cell types in neuroscience: Rebecca Hodge, Ph.D.

  • Cell types in Alzheimer's disease: Kyle Travaglini, Ph.D.

  • Q&A: all speakers

Audience members will be invited to submit questions for the speakers at any point in the program.

Speakers

Kimiko Domoto-Reilly, M.D.

University of Washington

Kimiko Domoto-Reilly, M.D., is a neurologist in the UW Memory and Brain Wellness Center, where she diagnoses and treats people with neurodegenerative dementias. She has expertise in atypical dementias, including frontotemporal degeneration spectrum disorders. She completed behavioral neurology fellowship training at Mass General Brigham in Boston, senior neuropsychiatry fellowship at MGH, and obtained a Master’s degree with a research focus on structural MR imaging in frontotemporal dementia. In collaboration with UW Alzheimer's Disease Research Center researchers, she studies autosomal dominantly-inherited neurodegenerative diseases, in order to better understand the factors influencing variation in age of onset, genetic penetrance, and disease progression.

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Rebecca Hodge, Ph.D.

Allen Institute for Brain Science

Rebecca Hodge is an Assistant Investigator and co-lead of genomics projects at the Allen Institute for Brain Science. She joined the Allen Institute as a Scientist II in the Human Cell Types program in March of 2014. Prior to joining the Institute, she completed her postdoctoral research at the University of Washington and the Center for Integrative Brain Research at Seattle Children’s Research Institute. There, she studied the actions of transcription factors during the process of neurogenesis (the generation of neurons) in both the developing and adult brain. She completed her undergraduate training at Simon Fraser University where she received a B.Sc. in animal physiology. Her graduate training was completed in the Department of Pathology and Laboratory Medicine at the University of British Columbia in Vancouver, BC. Her Ph.D. work at UBC focused on the role of growth factors in regulating neural stem cell development and the generation of neurons during early development of the mammalian cerebral cortex.

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Caitlin Latimer, M.D., Ph.D.

University of Washington

Caitlin Latimer is an Assistant Professor in the Division of Neuropathology and the Department of Laboratory Medicine and Pathology at the University of Washington and co-leader of the Neuropathology core for the UW Alzheimer's Disease Research Center. She completed her M.D. and Ph.D. at the University of Kentucky prior to her residency in Anatomic Pathology and fellowship in Neuropathology at the University of Washington. Her research interests as a physician-scientist include investigating the underlying mechanisms of age-related neurodegenerative disease processes, particularly how multiple pathologic proteins may synergize to promote cognitive dysfunction with age.

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Ed Lein, Ph.D.

Allen Institute for Brain Science

Ed Lein is Senior Investigator at the Allen Institute for Brain Science and an Affiliate Professor in the Department of Neurological Surgery at the University of Washington. He leads the Human Cell Types program at the Allen Institute, focused on creating a cellular atlas of the human brain, understanding conserved and specialized features of human brain, developing tools for genetic access to specific cell types in non-genetically tractable organisms including human, and understanding cellular and molecular consequences of Alzheimer’s disease. He is also the Lead Investigator for the Alzheimer's center.

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Kyle Travaglini, Ph.D.

Allen Institute for Brain Science

Kyle Travaglini is a Scientist I at the Allen Institute for Brain Science. As a member of the Human Cell Types program, Kyle is focused on its project to characterize the molecular and cellular changes that underpin Alzheimer’s disease. Previously, he completed a Ph.D. in Biochemistry at Stanford University, where he constructed a single cell transcriptomic atlas of the human lung under the mentorship of Dr. Mark Krasnow. Prior to that, he conducted research with Dr. Steven Clark at the University of California, Los Angeles, where he received a B.S. in Biochemistry and identified a mechanism in yeast that helps ensure their proteins are built correctly.

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Moderator

Kaitlyn Casimo, Ph.D.

Allen Institute

Kaitlyn Casimo leads training programs and materials for scientists to learn how to use the open data resources and tools produced by the Allen Institute for Brain Science (brain-map.org) and Allen Institute for Cell Science (allencell.org). She also leads the programming and resources for high school and college educators, available at alleninstitute.org/learn. She received her BA in neuroscience from Pomona College and Ph.D. in neuroscience from the University of Washington, where she also received certificates in neural computation & engineering and science, technology, & society studies.

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