Ask Us Anything: Alzheimer’s Disease Brain Cell Atlas

The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) consortium has genetically profiled and mapped key brain regions from individuals affected by Alzheimer’s disease to uncover cell types, genetic patterns, and other biomarkers. Resulting massive datasets from this research are openly available to speed discovery.

On Sept. 12, between 9am-2pm (PT) join our Reddit AMA (Ask Me Anything) with scientists from Allen Institute and UW Medicine to ask questions and learn more about this research.

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Cell by cell, scientists are building a high-resolution map of brain changes in Alzheimer’s disease

There is every reason to believe that Alzheimer's disease has its roots in specific types of brain cells. That's why Allen Institute scientists, together with collaborators at UW Medicine and Kaiser Permanente Washington Health Research Institute and with support from the National Institute on Aging, are taking a new kind of approach, cell by cell, to understand the disease. They've just released their first dataset, from 1.2M brain cells, that hints at the kinds of cells that die off or change in the neurodegenerative disease.

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Participating Scientists

Jeremy Miller, Ph.D.
Senior Scientist, Allen Institute

Dr. Miller joined the Allen Institute in 2011 to help with computational data analysis of the Allen Human Brain Atlas project. He is first author on several major manuscripts describing the Allen Institute’s large-scale transcriptomic resources on the adult and developing human and non-human primate brain, including the Aging, Dementia, and Traumatic Brain Injury Study. Miller received his Ph.D. in neuroscience from UCLA, where he studied gene expression changes in the brain in Alzheimer's disease and normal aging in the lab of Dr. Daniel Geschwind. 

Kyle Travaglini, Ph.D. 
Scientist I, Allen Institute

Kyle Travaglini is a Scientist at the Allen Institute for Brain Science. As a member of the Human Cell Types program, Kyle is focused on characterizing the molecular and cellular changes that underpin Alzheimer’s disease. Previously, he completed a Ph.D. in Biochemistry at Stanford University, where he constructed a single cell transcriptomic atlas of the human lung under the mentorship of Dr. Mark Krasnow. Prior to that, he conducted research with Dr. Steven Clark at the University of California, Los Angeles, where he received a B.S. in Biochemistry and identified a mechanism in yeast that helps ensure their proteins are built correctly. 

Shubhabrata “Joey” Mukherjee, Ph.D., M.S.
Assistant Professor, UW Department of Medicine

Dr. Shubhabrata is trained in statistics, psychometrics, and genetics related to Alzheimer's disease research. He is an active member of the AD Genetics Consortium (ADGC) and the International Genomics of Alzheimer’s project (IGAP). 

Jeanelle Ariza Torres
Research Scientist, UW Medicine

Jeanelle Ariza Torres, is a Research Scientist at the UW Medicine Biorepository and Integrated Research (BRaIN) laboratory at the University of Washington. She is the leader for the neuropathology quantification efforts using the whole slide image analysis in FFPE analysis and Luminex from human brain tissue extractions.