Team

Staff Profiles

Jack Waters, Ph.D.

Associate Investigator

Jack Waters is an Associate Investigator in the Neural Coding group. He leads a team who investigate the cellular and circuit mechanisms underlying changes in cortical physiology with behavior. Before joining the Allen Institute for Brain Science, he held postdoctoral positions at Stanford University and the Max Planck Institute for Medical Research in Heidelberg, Germany, and was an Assistant Professor in the Department of Physiology at Northwestern University in Chicago. Previous research includes pioneering the combination of electrophysiology and 2-photon imaging techniques to study cells and circuits in intact rodents and examining how ongoing synaptic activity modulates the excitability of neocortical pyramidal neurons in vivo. He also developed the application of optogenetics to control the release of acetylcholine in neocortex and established that nicotinic acetylcholine receptors play a large role in shaping the effects of acetylcholine on neocortical pyramidal neurons. Waters holds a BSc in Biochemistry from the University of York and a PhD in Pharmacology from University College London.

Selected Publications

Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

bioRxiv
September 12, 2018

Waters J, Lee E, Gaudreault N, Griffin F, Lecoq J, Slaughterbeck C, Sullivan D, Farrell C, Perkins J, Reid D, Feng D, Graddis N, Garrett M, Li Y, Long F, Mochizuki C, Roll K, Zhuang J, Thompson C

A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality

Cell
July 12, 2018

Daigle TL, Madisen L, Hage TA, Valley MT, Knoblich U, Larsen RS, Takeno MM, Huang L, Gu H, Larsen R, Mills M, Bosma-Moody A, Siverts LA, Walker M, Graybuck LT, Yao Z, Fong O, Nguyen TN, Garren E, Lenz GH, Chavarha M, Pendergraft J, Harrington J, Hirokawa KE, Harris JA, Nicovich PR, McGraw MJ, Ollerenshaw DR, Smith KA, Baker CA, Ting JT, Sunkin SM, Lecoq J, Lin MZ2, Boyden ES, Murphy GJ, da Costa NM, Waters J, Li L, Tasic B, Zeng H

A large-scale, standardized physiological survey reveals higher order coding throughout the mouse visual cortex

bioRxiv
June 29, 2018

de Vries S, Lecoq J, Buice MA, Groblewski PA, Ocker GK, Oliver M, Feng F, Cain N, Ledochowitsch P, Millman D, Roll K, Garrett M, Keenan T, Kuan L, Mihalas S, Olsen S, Thompson C, Wakeman W, Waters J, Williams D, Barber C, Berbesque N, Blanchard B, Bowles N, Caldejon S, Casal L, Cho A, Cross S, Dang C, Dolbeare T, Edwards M, Galbraith J, Gaudreault N, Griffin F, Hargrave P, Howard R, Huang L, Jewell S, Keller N, Knoblich U, Larkin J, Larsen R, Lau C, Lee E, Lee F, Leon A, Li L, Long F, Luviano J, Mace K, Nguyen T, Perkins J, Robertson M, Seid S, Shea-Brown E, Shi J, Sjoquist N, Slaughterbeck C, Sullivan D, Valenza R, White C, Williford A, Witten D, Zhuang J, Zeng H, Farrell C, Ng L, Bernard A, Phillips JW, R Reid C, Koch C

Neuromodulatory Correlates of Pupil Dilation

Frontiers in Neural Circuits
March 9, 2018

Larsen RS, Waters J

Activation of neuromodulatory axon projections in primary visual cortex during periods of locomotion and pupil dilation

bioRxiv
December 19, 2018

Larsen RS, Turschak E, Daigle T, Zeng H, Zhuang J, Waters J

Visual physiology of the Layer 4 cortical circuit in silico

PLoS Computational Biology
November 12, 2018

Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-LLavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C

Team

  • Bethanny Danskin - research associate who is testing the roles of the cholinergic system in shaping visually-guided behaviors.
  • Jun Zhang - visual physiologist interested in behavioral state-dependent processing of information in neocortex.
  • Rylan Larson - cellular physiologist who is studying the activity patterns of cholinergic neurons during visually-guided behavior.