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Viviana Gradinaru

California Institute of Technology

Dr. Viviana Gradinaru completed her B.S. at Caltech and her Ph.D. research at Stanford University. There she played an instrumental role in the early development and applications of optogenetics. During her doctoral studies Dr. Gradinaru also helped train scientists from all over the world in the Optogenetics Innovation Laboratory (OIL) and in summer courses at Cold Spring Harbor. During her postdoctoral work, also at Stanford with Dr. Karl Deisseroth, Dr. Gradinaru pioneered work towards a novel method for intact tissue mapping and phenotyping (known as CLARITY). Dr. Gradinaru is now Assistant Professor of Biology and Biological Engineering at Caltech as well as the faculty director of the Beckman Institute Optogenetics Neuroscience Initiative and CLARITY (BIONIC) Center. She has recently been awarded the NIH Director’s New Innovator Award and been honored as a World Economic Forum Young Scientist and as one of Cell’s 40 under 40. Viviana Gradinaru is also a Pew Scholar, Human Frontier Science Program Young Investigator, and Kimmel Scholar for Cancer Research. Dr. Gradinaru’s research interests focus on developing tools and methods for neuroscience (optogenetic actuators and sensors; tissue clearing and imaging) as well as on investigating the mechanisms underlying deep brain stimulation (DBS) and on the long-term effects of DBS on neuronal health, function, and ultimately behavior.

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featured publications

publication / 2023
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Nature Nanotechnology
publication / 2023
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Nature Communications
publication / 2023
Spatial transcriptomics for profiling the tropism of viral vectors in tissues
Nature Biotechnology
publication / 2021
Enhancer viruses for combinatorial cell-subclass-specific labeling
Neuron
publication / 2021
Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex
Cell Reports
publication / 2021
Dorsal Raphe Dopamine Neurons Signal Motivational Salience Dependent on Internal State, Expectation, and Behavioral Context
The Journal of Neuroscience
publication / 2020
RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations
Nature Methods
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