Disease knows no boundaries, but research often does.  

While illness affects all populations, our understanding of disease—and the effectiveness of treatments—varies dramatically across ethnic groups. This disparity stems from a longstanding bias in biomedical research, which has largely focused on European males, leaving much of our global population’s biology unexplored. 

Today, the Allen Institute for Cell Science and the New York Stem Cell Foundation (NYSCF) announced a pioneering collaboration to address this critical issue, combining two cutting-edge technologies to create more inclusive cellular models for studying disease. 

For this collaboration, NYSCF will use the Array® to gene-edit these diverse hiPSC lines with Allen Institute for Cell Science’s structure tags, allowing scientists to visualize critical aspects of cellular behavior. They will then convert the tagged hiPSCs into neurons and astrocytes, two cell types centrally implicated in Alzheimer’s and Parkinson’s disease. 

Notably, 9 of these stem cell lines were derived from nuns, priests, and brothers participating in the Religious Orders Study/Memory and Aging Project (ROSMAP) at Rush University Medical Center through a collaboration between Rush University, NYSCF, and Mass General Brigham. This unique cohort provides valuable insights into aging and cognitive health, adding another layer of significance to the resource.  

By integrating the Allen Institute’s cellular structure tags into these lines, the project aims to provide researchers with deeper insights into cellular biology that are inclusive and relevant to specific diseases, said Ru Gunawardane, Ph.D., executive vice president and director of the Allen Institute for Cell Science.  

“We are thrilled to partner with the New York Stem Cell Foundation to combine their expertise in generating hiPSC lines at scale with our advanced organelle tagging and rigorous quality control protocols,” Gunawardane said. “I’m excited by the potential impact of this collaboration, which will create a diverse and accessible stem cell resource to advance our understanding of cell biology in both normal and disease states.” 

Key aspects of the collaboration include: 

• Integration of Allen Institute for Cell Science’s structure tags into 24 of NYSCF’s stem cell lines (12 healthy, 6 with Alzheimer’s, 6 with Parkinson’s) 
• Creation of dual-tagged cell lines for enhanced study of cellular structures 
• Differentiation of tagged stem cells into neurons and astrocytes for neurological disease research
   

This initial phase of this partnership will demonstrate the power of combining these technologies to examine multiple cellular structures across diverse ancestral backgrounds and cell types. Future phases aim to expand the scope to include additional diseases and minority groups, develop new tagging technologies, and integrate more complex cellular models such as organoids. 

Media contact:  

David McKeon, Chief of Staff
New York Stem Cell Foundation 
dmckeon@nyscf.org
 

Peter Kim, Sr. Manager, Communications and Media Relations
Allen Institute 
206.605.9884 | peter.kim@alleninstitute.org