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We are leaders in large-scale research that transforms our understanding of human health and disease and shapes how science is conducted worldwide.
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To us, open science extends to inspiring the next generation of scientists by supporting access to science resources, research, and experiences.
A platform for high-throughput and reproducible neurophysiology open to external scientists to test theories of brain function
OpenScope opens the Allen Brain Observatory pipeline to the community, enabling theoretical, computational, and experimental scientists to test sophisticated hypotheses on brain function in a process analogous to astronomical observatories that survey the night sky.
Once a year, OpenScope will accept experimental proposals from external scientists, which will be reviewed by a panel of leading experts from the international community for their feasibility and scientific merit. The Allen Institute will carry out the selected in vivo experiments in mice brains following verified, reproducible, and open protocols for in vivo single- and multi-area two photon calcium imaging and Neuropixels electrophysiology, making the data freely available to these scientists and to the community. This will lower barriers to testing new hypotheses about brain function, bring new computational and theoretical talents into the field, and enhance the reproducibility of results in brain research, thereby accelerating progress toward an integrated understanding of neural activity in health and disease.
2022 Letter of Intent Due Date: Sept. 12, 2022
View 2022 RFP
Connect with us to learn more! View our OpenScope Applicant Webinar and schedule a 1:1 to consult on project proposals via [email protected].
End-to-end standardized experimental platform including brain surgery, animal training, neuronal recordings (in vivo electrophysiology or calcium imaging) and brain reconstruction.
Data standardization and sharing via NWB files in the cloud.
Yearly application cycle evaluating scientific proposals from the global scientific community.
Animal behavior training to test novel hypotheses of brain function.
2021 OPENSCOPE ANNUAL REPORT
2022 OpenScope Annual Report
OpenScope: The first shared observatory for neuroscience
The latest news on the OpenScope program.
All datasets collected on the platform are cross-referenced through shared standards and data access, allowing further meta-analysis and comparison by the community. An external team will need to analyze and then submit the outcome to bioRxiv and a journal. We don’t own the data, which will have restricted access for a one year period.
Access to the OpenScope program is available to scientists internationally. All experimental work is generously supported by an NIH U24 resource grant (U24 NS113646-01A1) to serve the global scientific community. The Allen Brain Observatory platform was initiated and established in 2016 thanks to funding from Paul G. Allen and the Falconwood Foundation.