Hindsight 2020 - The Allen Institute Developmental Recording Symposium

Join us March 3-5, 2020 at the Allen Institute for Hindsight 2020 - The Allen Institute Developmental Recording Symposium, a meeting featuring the latest insights from leading researchers in the fields of cell lineage and developmental recording, chaired by Jay Shendure, M.D., Ph.D. and Michael Elowitz, Ph.D., of the Allen Discovery Center at UW Medicine.

Understanding the lineages and molecular histories of individual cells is fundamental to understanding development and disease in multicellular organisms. Advances in genome engineering, genome editing, synthetic biology, single cell sequencing, and molecular imaging are enabling revolutionary approaches in which cells actively record their own histories to their genomes. These approaches are beginning to provide new insights into diverse developmental and disease processes. Hindsight 2020 will bring together researchers working on all aspects of this new field from technology development to biological inquiry. Winners of the Allen Institute Cell Lineage Reconstruction DREAM Challenge will also be announced at the event.

Click below to apply to attend the conference. Abstract submission for selected talks and posters has now closed.

View Agenda    Apply to attend



03/03/2020 to 03/05/2020

Allen Institute
615 Westlake Avenue N.
Seattle, WA 98109



  • Registration is via application, with no application fee.
  • The organizing committee will confirm registration applications regularly.

If you have any questions about your registration application, please contact

Event Overview

Tuesday, March 3:

  • Registration and breakfast (provided), 8:30-9:00am
  • Opening sessions, 9:00am-12:00pm
  • Networking lunch (provided) and optional Allen Institute tours, 12:00-2:00pm
  • Afternoon sessions, 2:00-5:30pm
  • Opening reception and poster session (heavy appetizers provided), 5:30-7:30pm

Wednesday, March 4:

  • Breakfast (provided), 8:30-9:00am
  • Morning sessions, 9:00-12:00pm
  • Networking lunch (provided), 12:00-1:30pm
  • Afternoon sessions, 1:30-5:30pm
  • DREAM Challenge session, 5:30-7:00pm
  • Dinner at MOHAI and keynote presentation, 7:00-9:30pm

Thursday, March 5:

  • Breakfast (provided), 8:30-9:00am
  • Morning sessions, 9:00am-12:00pm
  • Closing remarks, 12:00pm

View Agenda

Speakers include:

  • Detlev Arendt, EMBL Heidelberg
  • Constance Cepko, Harvard Medical School/HHMI
  • Michelle Chan, University of California, San Francisco
  • Lionel Christiaen, New York University
  • George Church, Harvard University
  • Jan Huisken, Morgridge Institute for Research
  • Celina Juliano, University of California, Davis
  • Jan Philipp Junker, Max Delbrueck Center for Molecular Medicine
  • Tzumin Lee, HHMI Janelia Research Campus
  • Prisca Liberali, Friedrich Miescher Institute for Biomedical Research
  • Carlos Lois, California Institute of Technology
  • Rong Lu, University of Southern California
  • Liqun Luo, Stanford University/HHMI
  • John Marioni, EMBL - European Bioinformatics Institute
  • Rob Mitra, Washington University School of Medicine
  • Samantha Morris, Washington University in St. Louis
  • Dana Pe'er, Sloan Kettering Institute
  • Kristy Red-Horse, Stanford University
  • Ellen Rothenberg, California Institute of Technology
  • Rahul Satija, New York Genome Center
  • Alex Schier, Biozentrum Basel
  • Cole Trapnell, University of Washington
  • Christopher Walsh, Harvard Medical School
  • Bob Waterston, University of Washington
  • Magdalena Zernicka-Goetz, University of Cambridge

Speaker bios & Talk info


Symposium Chairs

Jay Shendure, M.D., Ph.D.

Jay Shendure is an Investigator of the Howard Hughes Medical Institute, Professor of Genome Sciences at the University of Washington, and Director of the Allen Discovery Center for Cell Lineage Tracing. His 2005 PhD included one of the first successful demonstrations of massively parallel or next generation DNA sequencing. Dr. Shendure's research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders (e.g. Miller and Kabuki syndrome) and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays and saturation genome editing; whole organism lineage tracing; and massively parallel molecular profiling of single cells. He is the recipient of the 2012 Curt Stern Award from the American Society of Human Genetics, the 2013 FEDERAprijs, a 2013 NIH Director's Pioneer Award, and the 2014 HudsonAlpha Life Sciences Prize. He serves or has served on the Advisory Committee to the NIH Director, its Working Group on the US Precision Medicine Initiative, and the National Human Genome Research Advisory Council.

Michael Elowitz, Ph.D.

Michael Elowitz is an HHMI Investigator and Professor of Biology, Bioengineering, and Applied Physics at Caltech. He received his Ph.D. in Physics at Princeton in 1999, and did postdoctoral research at the Rockefeller University, before moving to Caltech in 2003. Dr. Elowitz's research has focused on understanding the design principles that allow circuits of interacting genes and proteins to perform their many critical and amazing functions in living cells. In 2000 he showed how a simple circuit of three repressor genes could produce clock-like protein oscillations in individual bacterial cells. This circuit, dubbed the Repressilator, helped start the new field of synthetic biology. He has also focused on the role of randomness, or 'noise', in the operation of genetic circuits, showing how noise originates in cells, how it impacts gene circuit dynamics, and how it can enable cells to control behaviors like differentiation in a probabilistic fashion. His laboratory has discovered new design principles of the Notch signaling pathways, revealed pulsatile operating modes in gene regulation systems, and analyzed the role of noise in the evolution of bacterial development. His laboratory is now bringing synthetic biology approaches to fundamental developmental problems underlying multicellular signaling, memory, and pattern formation. His work has been recognized by several awards, including fellowships from the Packard and Searle foundations, his selection as a Macarthur Fellow, and the HFSP Nakasone Award.