Join us March 3-5, 2020 at the Allen Institute for Hindsight 2020 - The Allen Institute Developmental Recording Symposium, a meeting featuring the latest insights from leading researchers in the fields of cell lineage and developmental recording, chaired by Jay Shendure, M.D., Ph.D. and Michael Elowitz, Ph.D., of the Allen Discovery Center at UW Medicine.
Understanding the lineages and molecular histories of individual cells is fundamental to understanding development and disease in multicellular organisms. Advances in genome engineering, genome editing, synthetic biology, single cell sequencing, and molecular imaging are enabling revolutionary approaches in which cells actively record their own histories to their genomes. These approaches are beginning to provide new insights into diverse developmental and disease processes. Hindsight 2020 will bring together researchers working on all aspects of this new field from technology development to biological inquiry.
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615 Westlake Avenue N.
Seattle, WA 98109
Tuesday, March 3:
- Registration and optional networking lunch (provided), 12:00-1:00pm
- Opening sessions, 1:00-5:00pm
- Opening reception and group dinner, 5:00-8:00pm
Wednesday, March 4:
- Breakfast (provided), 8:30-9:00am
- Morning sessions, 9:00-12:00pm
- Networking lunch (provided), 12:00-1:00pm
- Afternoon sessions, 1:00-5:00pm
- Reception and group dinner, 5:00-8:00pm
Thursday, March 5:
- Breakfast (provided), 8:30-9:00am
- Morning sessions, 9:00am-12:00pm
- Closing remarks, 12:00pm
Jay Shendure, M.D., Ph.D.
Jay Shendure is an Investigator of the Howard Hughes Medical Institute, Professor of Genome Sciences at the University of Washington, and Director of the Allen Discovery Center for Cell Lineage Tracing. His 2005 PhD included one of the first successful demonstrations of massively parallel or next generation DNA sequencing. Dr. Shendure's research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders (e.g. Miller and Kabuki syndrome) and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays and saturation genome editing; whole organism lineage tracing; and massively parallel molecular profiling of single cells. He is the recipient of the 2012 Curt Stern Award from the American Society of Human Genetics, the 2013 FEDERAprijs, a 2013 NIH Director's Pioneer Award, and the 2014 HudsonAlpha Life Sciences Prize. He serves or has served on the Advisory Committee to the NIH Director, its Working Group on the US Precision Medicine Initiative, and the National Human Genome Research Advisory Council.
Michael Elowitz, Ph.D.
Michael Elowitz is an HHMI Investigator and Professor of Biology, Bioengineering, and Applied Physics at Caltech. He received his Ph.D. in Physics at Princeton in 1999, and did postdoctoral research at the Rockefeller University, before moving to Caltech in 2003. Dr. Elowitz's research has focused on understanding the design principles that allow circuits of interacting genes and proteins to perform their many critical and amazing functions in living cells. In 2000 he showed how a simple circuit of three repressor genes could produce clock-like protein oscillations in individual bacterial cells. This circuit, dubbed the Repressilator, helped start the new field of synthetic biology. He has also focused on the role of randomness, or 'noise', in the operation of genetic circuits, showing how noise originates in cells, how it impacts gene circuit dynamics, and how it can enable cells to control behaviors like differentiation in a probabilistic fashion. His laboratory has discovered new design principles of the Notch signaling pathways, revealed pulsatile operating modes in gene regulation systems, and analyzed the role of noise in the evolution of bacterial development. His laboratory is now bringing synthetic biology approaches to fundamental developmental problems underlying multicellular signaling, memory, and pattern formation. His work has been recognized by several awards, including fellowships from the Packard and Searle foundations, his selection as a Macarthur Fellow, and the HFSP Nakasone Award.