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SciShots: A star-shaped human brain cell

Scientists catch a glimpse of a rare kind of human astrocyte

January 28, 2022

NoneWhat is a human brain cell but not a neuron? It sounds like a riddle, but our brains are full of other, lesser-known cells besides the textbook-famous electrical-signal-conducting neurons. Some of these cells, known collectively as glial cells, seem to be just as complicated as neurons but because they don’t send signals in the same way, are even harder to study in the lab. Shown here, in a microscopy image taken by Allen Institute for Brain Science Assistant Investigator Rebecca Hodge, Ph.D., a delicate type of brain cell known as an astrocyte, named for their star-like shape. Hodge and other Allen Institute scientists recently published a study that compares brain cell types, including astrocyte types, in the brains of mice, monkeys and humans. This particular human astrocyte appears to be a rare type known as a varicose projection astrocyte, so-called because it makes contact with blood vessels in the brain. This kind of astrocyte has only been found in the brains of humans and other apes. —Rachel Tompa, Ph.D.

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